Posttranscriptional upregulation of HER3 by HER2 mRNA induces trastuzumab resistance in breast cancer

Posttranscriptional upregulation of HER3 by HER2 mRNA induces trastuzumab resistance in breast cancer

Abstract Background HER2 gene amplification generates an enormous number of HER2 transcripts, but the global effects on endogenous miRNA targets including HER family members in breast cancer are unexplored. Methods We generated a HER2–3’UTR expressing vector to test the tumor-promoting properties in...

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Bibliographic Details
Main Authors: Xin Li, Yuxiu Xu, Yun Ding, Changfei Li, Hong Zhao, Jiandong Wang, Songdong Meng
Format: Article
Language:English
Published: BMC 2018-08-01
Series:Molecular Cancer
Subjects:
HER2
HER3
miR-125a/b
Trastuzumab resistance
Breast cancer
Online Access:http://link.springer.com/article/10.1186/s12943-018-0862-5

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