CX3CL1-Fc treatment prevents atherosclerosis in Ldlr KO mice

CX3CL1-Fc treatment prevents atherosclerosis in Ldlr KO mice

Objective: Atherosclerosis is a major cause of cardiovascular disease. Monocyte-endothelial cell interactions are partly mediated by expression of monocyte CX3CR1 and endothelial cell fractalkine (CX3CL1). Interrupting the interaction between this ligand–receptor pair should reduce monocyte binding...

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Bibliographic Details
Main Authors: Matthew Riopel, Melanie Vassallo, Erik Ehinger, Jennifer Pattison, Karen Bowden, Holger Winkels, Maria Wilson, Ron de Jong, Sanjay Patel, Deepika Balakrishna, James Bilakovics, Andrea Fanjul, Artur Plonowski, Christopher J. Larson, Klaus Ley, Pedro Cabrales, Joseph L. Witztum, Jerrold M. Olefsky, Yun Sok Lee
Format: Article
Language:English
Published: Elsevier 2019-02-01
Series:Molecular Metabolism
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877818306197

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