Small RNA zippers lock miRNA molecules and block miRNA function in mammalian cells

MicroRNAs regulate a wide range of biological processes and being able to inhibit their function could allow the development of therapeutic options. Here the authors describe a ‘small RNA zipper’ that sequesters miRNAs by forming a chain of DNA:RNA duplexes.

Bibliographic Details
Main Authors:	Lingyu Meng, Cuicui Liu, Jinhui Lü, Qian Zhao, Shengqiong Deng, Guangxue Wang, Jing Qiao, Chuyi Zhang, Lixiao Zhen, Ying Lu, Wenshu Li, Yuzhen Zhang, Richard G. Pestell, Huiming Fan, Yi-Han Chen, Zhongmin Liu, Zuoren Yu
Format:	Article
Language:	English
Published:	Nature Publishing Group 2017-01-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/ncomms13964

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spelling	doaj-9aa0306ca7c642ed86793ac064932e622021-05-11T07:04:51ZengNature Publishing GroupNature Communications2041-17232017-01-018111010.1038/ncomms13964Small RNA zippers lock miRNA molecules and block miRNA function in mammalian cellsLingyu Meng0Cuicui Liu1Jinhui Lü2Qian Zhao3Shengqiong Deng4Guangxue Wang5Jing Qiao6Chuyi Zhang7Lixiao Zhen8Ying Lu9Wenshu Li10Yuzhen Zhang11Richard G. Pestell12Huiming Fan13Yi-Han Chen14Zhongmin Liu15Zuoren Yu16Research Center for Translational Medicine, Key Laboratory of Arrhythmias of the Ministry of Education of China, East Hospital, Tongji University School of MedicineResearch Center for Translational Medicine, Key Laboratory of Arrhythmias of the Ministry of Education of China, East Hospital, Tongji University School of MedicineResearch Center for Translational Medicine, Key Laboratory of Arrhythmias of the Ministry of Education of China, East Hospital, Tongji University School of MedicineResearch Center for Translational Medicine, Key Laboratory of Arrhythmias of the Ministry of Education of China, East Hospital, Tongji University School of MedicineResearch Center for Translational Medicine, Key Laboratory of Arrhythmias of the Ministry of Education of China, East Hospital, Tongji University School of MedicineResearch Center for Translational Medicine, Key Laboratory of Arrhythmias of the Ministry of Education of China, East Hospital, Tongji University School of MedicineResearch Center for Translational Medicine, Key Laboratory of Arrhythmias of the Ministry of Education of China, East Hospital, Tongji University School of MedicineResearch Center for Translational Medicine, Key Laboratory of Arrhythmias of the Ministry of Education of China, East Hospital, Tongji University School of MedicineResearch Center for Translational Medicine, Key Laboratory of Arrhythmias of the Ministry of Education of China, East Hospital, Tongji University School of MedicineResearch Center for Translational Medicine, Key Laboratory of Arrhythmias of the Ministry of Education of China, East Hospital, Tongji University School of MedicineSchool of Basic Medical Sciences, Wenzhou Medical UniversityResearch Center for Translational Medicine, Key Laboratory of Arrhythmias of the Ministry of Education of China, East Hospital, Tongji University School of MedicineDepartment of Cancer Biology, Sidney Kimmel Cancer Center, Thomas Jefferson UniversityResearch Center for Translational Medicine, Key Laboratory of Arrhythmias of the Ministry of Education of China, East Hospital, Tongji University School of MedicineResearch Center for Translational Medicine, Key Laboratory of Arrhythmias of the Ministry of Education of China, East Hospital, Tongji University School of MedicineResearch Center for Translational Medicine, Key Laboratory of Arrhythmias of the Ministry of Education of China, East Hospital, Tongji University School of MedicineResearch Center for Translational Medicine, Key Laboratory of Arrhythmias of the Ministry of Education of China, East Hospital, Tongji University School of MedicineMicroRNAs regulate a wide range of biological processes and being able to inhibit their function could allow the development of therapeutic options. Here the authors describe a ‘small RNA zipper’ that sequesters miRNAs by forming a chain of DNA:RNA duplexes.https://doi.org/10.1038/ncomms13964
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Lingyu Meng Cuicui Liu Jinhui Lü Qian Zhao Shengqiong Deng Guangxue Wang Jing Qiao Chuyi Zhang Lixiao Zhen Ying Lu Wenshu Li Yuzhen Zhang Richard G. Pestell Huiming Fan Yi-Han Chen Zhongmin Liu Zuoren Yu
spellingShingle	Lingyu Meng Cuicui Liu Jinhui Lü Qian Zhao Shengqiong Deng Guangxue Wang Jing Qiao Chuyi Zhang Lixiao Zhen Ying Lu Wenshu Li Yuzhen Zhang Richard G. Pestell Huiming Fan Yi-Han Chen Zhongmin Liu Zuoren Yu Small RNA zippers lock miRNA molecules and block miRNA function in mammalian cells Nature Communications
author_facet	Lingyu Meng Cuicui Liu Jinhui Lü Qian Zhao Shengqiong Deng Guangxue Wang Jing Qiao Chuyi Zhang Lixiao Zhen Ying Lu Wenshu Li Yuzhen Zhang Richard G. Pestell Huiming Fan Yi-Han Chen Zhongmin Liu Zuoren Yu
author_sort	Lingyu Meng
title	Small RNA zippers lock miRNA molecules and block miRNA function in mammalian cells
title_short	Small RNA zippers lock miRNA molecules and block miRNA function in mammalian cells
title_full	Small RNA zippers lock miRNA molecules and block miRNA function in mammalian cells
title_fullStr	Small RNA zippers lock miRNA molecules and block miRNA function in mammalian cells
title_full_unstemmed	Small RNA zippers lock miRNA molecules and block miRNA function in mammalian cells
title_sort	small rna zippers lock mirna molecules and block mirna function in mammalian cells
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2017-01-01
description	MicroRNAs regulate a wide range of biological processes and being able to inhibit their function could allow the development of therapeutic options. Here the authors describe a ‘small RNA zipper’ that sequesters miRNAs by forming a chain of DNA:RNA duplexes.
url	https://doi.org/10.1038/ncomms13964
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Small RNA zippers lock miRNA molecules and block miRNA function in mammalian cells

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