Modification of diet in renal disease and Cockraft-Gaultformula accuracy in glomerular filtration rate estimation in Iranian adults

• Main Authors: Abdolamir Atapour, Kalantari Elham, Shahrzad Shahidi, Mojgan Mortazavi Najafabadi, Parin Hedayati
• Format: Article
• Language: English
• Published: Wolters Kluwer Medknow Publications 2013-01-01
• Series: Advanced Biomedical Research
• Subjects: Cockraft-Gault formula; chronic kidney disease; glomerular filtration rate; modification of diet in renal disease; TC99m-Labeled diethylene triamine penta acetic acid
• Online Access: http://www.advbiores.net/article.asp?issn=2277-9175;year=2013;volume=2;issue=1;spage=32;epage=32;aulast=Atapour

Introduction: The aim of this study was to evaluate the accuracy of modification of diet in renal disease (MDRD) and Cockraft-Gault (C-G) formulas for estimating GFR in a sample of Iranian adult. Materials and Methods: This study was an analytic cross-sectional study on 54 patients with chronic kidney disease. Glomerular filtration rate was measured by kidney scan via TC99m-labeled diethylenetriaminepentaacetic acid, and it was estimated by MDRD and Cockraft-Gault formulas. Results: The mean of measured GFR and estimated GFR by MDRD and C-G formulas was 61.64 ± 34.26 ml/min, 51.80 ± 25.47, and 54.29 ± 24 ml/min respectively (P-value < 0.001, r = 0.818 and P-value < 0.001, r = 0.847, respectively). Pearson correlation test showed direct linear relationship between sGFR and GFR as estimated by the Cockraft-Gault and MDRD formulas. Conclusion: Based on our results, modification of diet in renal disease (MDRD) and Cockraf-Gault (C-G) formulas are accurate formulas in Iranian adults but they need a correction factor.