Negri bodies are viral factories with properties of liquid organelles

Negri bodies are viral factories with properties of liquid organelles

Negative strand RNA viruses, such as rabies virus, induce formation of cytoplasmic inclusions for genome replication. Here, Nikolic et al. show that these so-called Negri bodies (NBs) have characteristics of liquid organelles and they identify the minimal protein domains required for NB formation.

Bibliographic Details
Main Authors: Jovan Nikolic, Romain Le Bars, Zoé Lama, Nathalie Scrima, Cécile Lagaudrière-Gesbert, Yves Gaudin, Danielle Blondel
Format: Article
Language:English
Published: Nature Publishing Group 2017-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-00102-9
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spelling doaj-9a955e81f9324d589e3ef61679b3fd392021-01-31T12:32:41ZengNature Publishing GroupNature Communications2041-17232017-07-018111310.1038/s41467-017-00102-9Negri bodies are viral factories with properties of liquid organellesJovan Nikolic0Romain Le Bars1Zoé Lama2Nathalie Scrima3Cécile Lagaudrière-Gesbert4Yves Gaudin5Danielle Blondel6Institute for Integrative Biology of the Cell (I2BC), CEA, CNRS, Univ. Paris-Sud, Université Paris-SaclayInstitute for Integrative Biology of the Cell (I2BC), CEA, CNRS, Univ. Paris-Sud, Université Paris-SaclayInstitute for Integrative Biology of the Cell (I2BC), CEA, CNRS, Univ. Paris-Sud, Université Paris-SaclayInstitute for Integrative Biology of the Cell (I2BC), CEA, CNRS, Univ. Paris-Sud, Université Paris-SaclayInstitute for Integrative Biology of the Cell (I2BC), CEA, CNRS, Univ. Paris-Sud, Université Paris-SaclayInstitute for Integrative Biology of the Cell (I2BC), CEA, CNRS, Univ. Paris-Sud, Université Paris-SaclayInstitute for Integrative Biology of the Cell (I2BC), CEA, CNRS, Univ. Paris-Sud, Université Paris-SaclayNegative strand RNA viruses, such as rabies virus, induce formation of cytoplasmic inclusions for genome replication. Here, Nikolic et al. show that these so-called Negri bodies (NBs) have characteristics of liquid organelles and they identify the minimal protein domains required for NB formation.https://doi.org/10.1038/s41467-017-00102-9
collection DOAJ
language English
format Article
sources DOAJ
author Jovan Nikolic
Romain Le Bars
Zoé Lama
Nathalie Scrima
Cécile Lagaudrière-Gesbert
Yves Gaudin
Danielle Blondel
spellingShingle Jovan Nikolic
Romain Le Bars
Zoé Lama
Nathalie Scrima
Cécile Lagaudrière-Gesbert
Yves Gaudin
Danielle Blondel
Negri bodies are viral factories with properties of liquid organelles
Nature Communications
author_facet Jovan Nikolic
Romain Le Bars
Zoé Lama
Nathalie Scrima
Cécile Lagaudrière-Gesbert
Yves Gaudin
Danielle Blondel
author_sort Jovan Nikolic
title Negri bodies are viral factories with properties of liquid organelles
title_short Negri bodies are viral factories with properties of liquid organelles
title_full Negri bodies are viral factories with properties of liquid organelles
title_fullStr Negri bodies are viral factories with properties of liquid organelles
title_full_unstemmed Negri bodies are viral factories with properties of liquid organelles
title_sort negri bodies are viral factories with properties of liquid organelles
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2017-07-01
description Negative strand RNA viruses, such as rabies virus, induce formation of cytoplasmic inclusions for genome replication. Here, Nikolic et al. show that these so-called Negri bodies (NBs) have characteristics of liquid organelles and they identify the minimal protein domains required for NB formation.
url https://doi.org/10.1038/s41467-017-00102-9
work_keys_str_mv AT jovannikolic negribodiesareviralfactorieswithpropertiesofliquidorganelles
AT romainlebars negribodiesareviralfactorieswithpropertiesofliquidorganelles
AT zoelama negribodiesareviralfactorieswithpropertiesofliquidorganelles
AT nathaliescrima negribodiesareviralfactorieswithpropertiesofliquidorganelles
AT cecilelagaudrieregesbert negribodiesareviralfactorieswithpropertiesofliquidorganelles
AT yvesgaudin negribodiesareviralfactorieswithpropertiesofliquidorganelles
AT danielleblondel negribodiesareviralfactorieswithpropertiesofliquidorganelles
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