Starved and asphyxiated: how can CD8+T cells within a tumor microenvironment prevent tumor progression
Although cancer immunotherapy has achieved significant breakthroughs in recent years, its overall efficacy remains limited in the majority of patients. One major barrier is exhaustion of tumor antigen (TA)-specific CD8+ tumor-infiltrating lymphocytes (TILs), which conventionally has been attribute...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2016-02-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00032/full |