Loss of FOXC1 contributes to the corneal epithelial fate switch and pathogenesis

Loss of FOXC1 contributes to the corneal epithelial fate switch and pathogenesis

Abstract Forkhead box C1 (FOXC1) is required for neural crest and ocular development, and mutations in FOXC1 lead to inherited Axenfeld–Rieger syndrome. Here, we find that FOXC1 and paired box 6 (PAX6) are co-expressed in the human limbus and central corneal epithelium. Deficiency of FOXC1 and alter...

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Main Authors: Mingsen Li, Liqiong Zhu, Jiafeng Liu, Huaxing Huang, Huizhen Guo, Li Wang, Lingyu Li, Sijie Gu, Jieying Tan, Jing Zhong, Bowen Wang, Zhen Mao, Yong Fan, Chunqiao Liu, Jin Yuan, Hong Ouyang
Format: Article
Language:English
Published: Nature Publishing Group 2021-01-01
Series:Signal Transduction and Targeted Therapy
Online Access:https://doi.org/10.1038/s41392-020-00378-2

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