Genetic polymorphisms namely TLR2 Gene Arg753gln and Arg677trp polymorphisms and tuberculosis: Comparison on the effects of molecular weight alterations

• Main Authors: Pathum Sookaromdee, Viroj Wiwanitkit, Beuy Joob
• Format: Article
• Language: English
• Published: Wolters Kluwer Medknow Publications 2019-01-01
• Series: Biomedical and Biotechnology Research Journal
• Subjects: Effect; genetic; polymorphism; tuberculosis
• Online Access: http://www.bmbtrj.org/article.asp?issn=2588-9834;year=2019;volume=3;issue=2;spage=129;epage=130;aulast=Sookaromdee

Background: Tuberculosis is an important mycobacterial infection. This problem is still the present public health problem in several countries around the world. The genetic underlying factor is usually mentioned for the effect on the natural history of tuberculosis infection. Methods: Here, the authors perform a standard assessment on the molecular change due to TLR2 gene Arg753Gln and Arg677Trp polymorphisms and further study on the effect on the corresponding phenotypic expression changes. Results: The molecular weight changes comparing to naïve molecule in cases of Arg753Gln and Arg677Trp polymorphisms are equal to –16.1% and +17.2%, respectively. Conclusion: According to the molecular structure analysis, Arg753Gln has a relationship with active tuberculosis whereas Arg677Trp polymorphism is not.