Cardio-autonomic functions and sleep indices before and after coronary artery bypass surgery

• Main Authors: Khamis Mohammed Al-Hashmi, Mohammed A Al-Abri, Deepali S Jaju, Mirdavron Mukaddirov, Abdulnasir Hossen, Mohammed O Hassan, Mostafa Mesbah, Hilal Ali Al-Sabti
• Format: Article
• Language: English
• Published: Wolters Kluwer Medknow Publications 2018-01-01
• Series: Annals of Thoracic Medicine
• Subjects: Apnea/hypopnea index; heart rate variability (HRV); ischemic heart disease (IHD); sympathetic component; vagal component
• Online Access: http://www.thoracicmedicine.org/article.asp?issn=1817-1737;year=2018;volume=13;issue=1;spage=14;epage=21;aulast=Al-Hashmi
• ISSN: 1817-1737; 1998-3557

BACKGROUND: Earlier studies showed a short-term impairment of cardio-autonomic functions following coronary artery bypass grafting (CABG). There is a lack of consistency in the time of recovery from this impairment. Studies have attributed the post-CABG atrial fibrillation to preexisting obstructive sleep apnea (OSA) without an objective sleep assessment. The aim of this study was to evaluate the effect of CABG on cardio-autonomic and hemodynamic functions and on OSA indices in patients with ischemic heart disease (IHD). METHODS: Cardio-autonomic function using heart rate variability indices, hemodynamic parameters, and sleep studies were performed in 26 patients with stable IHD before, on day-6, and day-30 post-CABG surgery. RESULTS: The high-frequency powers of normalized R-R intervals significantly (P = 0.002) increased from the preoperative value of 46.09 to 66.52 on day-6 and remained unchanged on day-30 postsurgery. In contrary, the low-frequency powers of normalized R-R interval decreased from 53.91 to 33.48 during the same period (P = 0.002) and remained unchanged on day 30 postsurgery. Baroreceptor sensitivity, obstructive and central apnea indices, desaturation index, and lowest O2 saturation were not significantly different between preoperative, day-6, and day-30 postsurgery. CONCLUSION: Our study revealed that recovery of autonomic functions following CABG occurs as early as 30 days of postsurgery. CABG does not seem to have short-term effects on sleep study indices. However, long-term effects need further evaluation.