HTLV-1 Tax Functions as a Ubiquitin E3 Ligase for Direct IKK Activation via Synthesis of Mixed-Linkage Polyubiquitin Chains.

HTLV-1 Tax Functions as a Ubiquitin E3 Ligase for Direct IKK Activation via Synthesis of Mixed-Linkage Polyubiquitin Chains.

The HTLV-1 oncoprotein Tax plays a key role in CD4+ T cell transformation by promoting cell proliferation and survival, mainly through permanent activation of the NK-κB pathway and induction of many NF-κB target genes. Elucidating the underlying molecular mechanism is therefore critical in understan...

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Bibliographic Details
Main Authors: Chong Wang, Wenying Long, Chao Peng, Lin Hu, Qiong Zhang, Ailing Wu, Xiaoqing Zhang, Xiaotao Duan, Catherine C L Wong, Yuetsu Tanaka, Zongping Xia
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-04-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC4833305?pdf=render

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http://europepmc.org/articles/PMC4833305?pdf=render

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