A Novel Oncolytic Chimeric Orthopoxvirus Encoding Luciferase Enables Real-Time View of Colorectal Cancer Cell Infection

A Novel Oncolytic Chimeric Orthopoxvirus Encoding Luciferase Enables Real-Time View of Colorectal Cancer Cell Infection

This study hypothesizes that a novel oncolytic chimeric orthopoxvirus CF33-Fluc is imageable and targets colorectal cancer cells (CRCs). A novel chimeric orthopoxvirus (CF33) was constructed. The thymidine kinase locus was replaced with firefly luciferase (Fluc) to yield a recombinant virus—CF33-Flu...

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Bibliographic Details
Main Authors: Michael P. O’Leary, Susanne G. Warner, Sang-In Kim, Shyambabu Chaurasiya, Jianming Lu, Audrey H. Choi, Anthony K. Park, Yanghee Woo, Yuman Fong, Nanhai G. Chen
Format: Article
Language:English
Published: Elsevier 2018-06-01
Series:Molecular Therapy: Oncolytics
Online Access:http://www.sciencedirect.com/science/article/pii/S2372770518300056

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