Hydrodynamic and Electrophoretic Properties of Trastuzumab/HER2 Extracellular Domain Complexes as Revealed by Experimental Techniques and Computational Simulations

Hydrodynamic and Electrophoretic Properties of Trastuzumab/HER2 Extracellular Domain Complexes as Revealed by Experimental Techniques and Computational Simulations

The combination of hydrodynamic and electrophoretic experiments and computer simulations is a powerful approach to study the interaction between proteins. In this work, we present hydrodynamic and electrophoretic experiments in an aqueous solution along with molecular dynamics and hydrodynamic model...

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Bibliographic Details
Main Authors: Javier Ramos, Juan Francisco Vega, Victor Cruz, Eduardo Sanchez-Sanchez, Javier Cortes, Javier Martinez-Salazar
Format: Article
Language:English
Published: MDPI AG 2019-03-01
Series:International Journal of Molecular Sciences
Subjects:
Trastuzumab/HER2 complexes
conformational fluctuations
hydrodynamic properties
molecular dynamics
Online Access:http://www.mdpi.com/1422-0067/20/5/1076

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