A Dual Targeting Magnetic Nanoparticle for Human Cancer Detection

Abstract Malignant tumors are a major threat to human life and high lymphatic vessel density is often associated with metastatic tumors. With the discovery of molecules targeted at the lymphatic system such as lymphatic vessel endothelial hyaluronan receptor 1 (LYVE-1) and Podoplanin, many studies h...

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Main Authors:	Siwen Wu, Xiyu Liu, Jian He, Huiling Wang, Yiqun Luo, Wenlin Gong, Yanmei Li, Yong Huang, Liping Zhong, Yongxiang Zhao
Format:	Article
Language:	English
Published:	SpringerOpen 2019-07-01
Series:	Nanoscale Research Letters
Subjects:	Lymphatic endothelial cells Podoplanin LYVE-1 Magnetic nanoparticles
Online Access:	http://link.springer.com/article/10.1186/s11671-019-3049-0

id	doaj-9a47c1fd1e8944db8c46d66daf2a9c60
record_format	Article
spelling	doaj-9a47c1fd1e8944db8c46d66daf2a9c602020-11-25T03:36:42ZengSpringerOpenNanoscale Research Letters1931-75731556-276X2019-07-0114111110.1186/s11671-019-3049-0A Dual Targeting Magnetic Nanoparticle for Human Cancer DetectionSiwen Wu0Xiyu Liu1Jian He2Huiling Wang3Yiqun Luo4Wenlin Gong5Yanmei Li6Yong Huang7Liping Zhong8Yongxiang Zhao9National Center for International Research of Bio-targeting Theranostics, Guangxi Key Laboratory of Bio-targeting Theranostics, Collaborative InnovationCenter for Targeting Tumor Diagnosis and Therapy, Guangxi Medical UniversityNational Center for International Research of Bio-targeting Theranostics, Guangxi Key Laboratory of Bio-targeting Theranostics, Collaborative InnovationCenter for Targeting Tumor Diagnosis and Therapy, Guangxi Medical UniversityNational Center for International Research of Bio-targeting Theranostics, Guangxi Key Laboratory of Bio-targeting Theranostics, Collaborative InnovationCenter for Targeting Tumor Diagnosis and Therapy, Guangxi Medical UniversityNational Center for International Research of Bio-targeting Theranostics, Guangxi Key Laboratory of Bio-targeting Theranostics, Collaborative InnovationCenter for Targeting Tumor Diagnosis and Therapy, Guangxi Medical UniversityNational Center for International Research of Bio-targeting Theranostics, Guangxi Key Laboratory of Bio-targeting Theranostics, Collaborative InnovationCenter for Targeting Tumor Diagnosis and Therapy, Guangxi Medical UniversityNational Center for International Research of Bio-targeting Theranostics, Guangxi Key Laboratory of Bio-targeting Theranostics, Collaborative InnovationCenter for Targeting Tumor Diagnosis and Therapy, Guangxi Medical UniversityNational Center for International Research of Bio-targeting Theranostics, Guangxi Key Laboratory of Bio-targeting Theranostics, Collaborative InnovationCenter for Targeting Tumor Diagnosis and Therapy, Guangxi Medical UniversityNational Center for International Research of Bio-targeting Theranostics, Guangxi Key Laboratory of Bio-targeting Theranostics, Collaborative InnovationCenter for Targeting Tumor Diagnosis and Therapy, Guangxi Medical UniversityNational Center for International Research of Bio-targeting Theranostics, Guangxi Key Laboratory of Bio-targeting Theranostics, Collaborative InnovationCenter for Targeting Tumor Diagnosis and Therapy, Guangxi Medical UniversityNational Center for International Research of Bio-targeting Theranostics, Guangxi Key Laboratory of Bio-targeting Theranostics, Collaborative InnovationCenter for Targeting Tumor Diagnosis and Therapy, Guangxi Medical UniversityAbstract Malignant tumors are a major threat to human life and high lymphatic vessel density is often associated with metastatic tumors. With the discovery of molecules targeted at the lymphatic system such as lymphatic vessel endothelial hyaluronan receptor 1 (LYVE-1) and Podoplanin, many studies have been performed to determine the role of lymphatic endothelial cells (LECs) in tumor metastasis. However, disadvantages such as non-specificity and high cost limit their research and diagnostic applications. In this study, Fe3O4@KCTS, a core-shell type of magnetic nanoparticles, was prepared by activating Fe3O4 with carbodiimide and cross-linking it with α-ketoglutarate chitosan (KCTS). The LYVE-1 and Podoplanin antibodies were then incorporated onto the surface of these magnetic nanoparticles and as a result, dual-targeting magnetic nanoprobes were developed. The experimental tests of this study demonstrated that a dual-targeting magnetic nanoprobe with high-purity LECs from tumor tissues was successfully developed, providing a basis for clinical application of LECs in colorectal cancer treatment as well as in early clinical diagnosis using bimodal imaging.http://link.springer.com/article/10.1186/s11671-019-3049-0Lymphatic endothelial cellsPodoplaninLYVE-1Magnetic nanoparticles
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Siwen Wu Xiyu Liu Jian He Huiling Wang Yiqun Luo Wenlin Gong Yanmei Li Yong Huang Liping Zhong Yongxiang Zhao
spellingShingle	Siwen Wu Xiyu Liu Jian He Huiling Wang Yiqun Luo Wenlin Gong Yanmei Li Yong Huang Liping Zhong Yongxiang Zhao A Dual Targeting Magnetic Nanoparticle for Human Cancer Detection Nanoscale Research Letters Lymphatic endothelial cells Podoplanin LYVE-1 Magnetic nanoparticles
author_facet	Siwen Wu Xiyu Liu Jian He Huiling Wang Yiqun Luo Wenlin Gong Yanmei Li Yong Huang Liping Zhong Yongxiang Zhao
author_sort	Siwen Wu
title	A Dual Targeting Magnetic Nanoparticle for Human Cancer Detection
title_short	A Dual Targeting Magnetic Nanoparticle for Human Cancer Detection
title_full	A Dual Targeting Magnetic Nanoparticle for Human Cancer Detection
title_fullStr	A Dual Targeting Magnetic Nanoparticle for Human Cancer Detection
title_full_unstemmed	A Dual Targeting Magnetic Nanoparticle for Human Cancer Detection
title_sort	dual targeting magnetic nanoparticle for human cancer detection
publisher	SpringerOpen
series	Nanoscale Research Letters
issn	1931-7573 1556-276X
publishDate	2019-07-01
description	Abstract Malignant tumors are a major threat to human life and high lymphatic vessel density is often associated with metastatic tumors. With the discovery of molecules targeted at the lymphatic system such as lymphatic vessel endothelial hyaluronan receptor 1 (LYVE-1) and Podoplanin, many studies have been performed to determine the role of lymphatic endothelial cells (LECs) in tumor metastasis. However, disadvantages such as non-specificity and high cost limit their research and diagnostic applications. In this study, Fe3O4@KCTS, a core-shell type of magnetic nanoparticles, was prepared by activating Fe3O4 with carbodiimide and cross-linking it with α-ketoglutarate chitosan (KCTS). The LYVE-1 and Podoplanin antibodies were then incorporated onto the surface of these magnetic nanoparticles and as a result, dual-targeting magnetic nanoprobes were developed. The experimental tests of this study demonstrated that a dual-targeting magnetic nanoprobe with high-purity LECs from tumor tissues was successfully developed, providing a basis for clinical application of LECs in colorectal cancer treatment as well as in early clinical diagnosis using bimodal imaging.
topic	Lymphatic endothelial cells Podoplanin LYVE-1 Magnetic nanoparticles
url	http://link.springer.com/article/10.1186/s11671-019-3049-0
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A Dual Targeting Magnetic Nanoparticle for Human Cancer Detection

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