Within-host evolution of Helicobacter pylori shaped by niche-specific adaptation, intragastric migrations and selective sweeps

Helicobacter pylori, a bacterial pathogen that infects human stomachs, has high genetic diversity across hosts. Here, Ailloud et al. reveal genetic structuring of H. pylori populations among different stomach regions of individual hosts and find signals of genetic associations with stomach region.

Bibliographic Details
Main Authors:	Florent Ailloud, Xavier Didelot, Sabrina Woltemate, Gudrun Pfaffinger, Jörg Overmann, Ruth Christiane Bader, Christian Schulz, Peter Malfertheiner, Sebastian Suerbaum
Format:	Article
Language:	English
Published:	Nature Publishing Group 2019-05-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-019-10050-1

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spelling	doaj-9a3e48a0d62246e483c72c41e2e859022021-05-11T11:35:20ZengNature Publishing GroupNature Communications2041-17232019-05-0110111310.1038/s41467-019-10050-1Within-host evolution of Helicobacter pylori shaped by niche-specific adaptation, intragastric migrations and selective sweepsFlorent Ailloud0Xavier Didelot1Sabrina Woltemate2Gudrun Pfaffinger3Jörg Overmann4Ruth Christiane Bader5Christian Schulz6Peter Malfertheiner7Sebastian Suerbaum8Department of Medical Microbiology and Hospital Epidemiology, Max von Pettenkofer Institute, Faculty of Medicine, LMU MunichSchool of Life Sciences, University of WarwickInstitute of Medical Microbiology and Hospital Epidemiology, MHH Hannover Medical SchoolDepartment of Medical Microbiology and Hospital Epidemiology, Max von Pettenkofer Institute, Faculty of Medicine, LMU MunichDZIF German Center for Infection Research, Hannover-Braunschweig SiteDepartment of Medical Microbiology and Hospital Epidemiology, Max von Pettenkofer Institute, Faculty of Medicine, LMU MunichDepartment of Gastroenterology, Hepatology and Infectious Diseases, Otto von Guericke UniversityDepartment of Gastroenterology, Hepatology and Infectious Diseases, Otto von Guericke UniversityDepartment of Medical Microbiology and Hospital Epidemiology, Max von Pettenkofer Institute, Faculty of Medicine, LMU MunichHelicobacter pylori, a bacterial pathogen that infects human stomachs, has high genetic diversity across hosts. Here, Ailloud et al. reveal genetic structuring of H. pylori populations among different stomach regions of individual hosts and find signals of genetic associations with stomach region.https://doi.org/10.1038/s41467-019-10050-1
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Florent Ailloud Xavier Didelot Sabrina Woltemate Gudrun Pfaffinger Jörg Overmann Ruth Christiane Bader Christian Schulz Peter Malfertheiner Sebastian Suerbaum
spellingShingle	Florent Ailloud Xavier Didelot Sabrina Woltemate Gudrun Pfaffinger Jörg Overmann Ruth Christiane Bader Christian Schulz Peter Malfertheiner Sebastian Suerbaum Within-host evolution of Helicobacter pylori shaped by niche-specific adaptation, intragastric migrations and selective sweeps Nature Communications
author_facet	Florent Ailloud Xavier Didelot Sabrina Woltemate Gudrun Pfaffinger Jörg Overmann Ruth Christiane Bader Christian Schulz Peter Malfertheiner Sebastian Suerbaum
author_sort	Florent Ailloud
title	Within-host evolution of Helicobacter pylori shaped by niche-specific adaptation, intragastric migrations and selective sweeps
title_short	Within-host evolution of Helicobacter pylori shaped by niche-specific adaptation, intragastric migrations and selective sweeps
title_full	Within-host evolution of Helicobacter pylori shaped by niche-specific adaptation, intragastric migrations and selective sweeps
title_fullStr	Within-host evolution of Helicobacter pylori shaped by niche-specific adaptation, intragastric migrations and selective sweeps
title_full_unstemmed	Within-host evolution of Helicobacter pylori shaped by niche-specific adaptation, intragastric migrations and selective sweeps
title_sort	within-host evolution of helicobacter pylori shaped by niche-specific adaptation, intragastric migrations and selective sweeps
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2019-05-01
description	Helicobacter pylori, a bacterial pathogen that infects human stomachs, has high genetic diversity across hosts. Here, Ailloud et al. reveal genetic structuring of H. pylori populations among different stomach regions of individual hosts and find signals of genetic associations with stomach region.
url	https://doi.org/10.1038/s41467-019-10050-1
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Within-host evolution of Helicobacter pylori shaped by niche-specific adaptation, intragastric migrations and selective sweeps

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