Glucose-dependent insulinotropic peptide receptor overexpression in adrenocortical hyperplasia in MEN1 syndrome without loss of heterozygosity at the 11q13 locus

Glucose-dependent insulinotropic peptide receptor overexpression in adrenocortical hyperplasia in MEN1 syndrome without loss of heterozygosity at the 11q13 locus

BACKGROUND: The molecular mechanisms involved in the genesis of the adrenocortical lesions seen in MEN1 syndrome (ACL-MEN1) remain poorly understood; loss of heterozygosity at 11q13 and somatic mutations of MEN1 are not usually found in these lesions. Thus, additional genes must be involved in MEN1...

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Bibliographic Details
Main Authors: Marcia Helena Soares Costa, Sorahia Domenice, Rodrigo Almeida Toledo, Delmar Muniz L. Junior, Ana Claudia Latronico, Emilia Modolo Pinto, Sergio Pereira Almeida Toledo, Berenice Bilharinho Mendonca, Maria Candida Barisson Villares Fragoso
Format: Article
Language:English
Published: Faculdade de Medicina / USP 2011-01-01
Series:Clinics
Subjects:
MEN1
adrenocortical hyperplasia
GIPR
expression
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322011000400002

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