Protein Kinase C-δ Mediates Shedding of Angiotensin-Converting Enzyme 2 from Proximal Tubular Cells

Protein Kinase C-δ Mediates Shedding of Angiotensin-Converting Enzyme 2 from Proximal Tubular Cells

Angiotensin-converting enzyme 2 (ACE2) degrades angiotensin (Ang) II to Ang-(1-7), and protects against diabetic renal injury. Soluble ACE2 fragments are shed from the proximal tubule, and appear at high levels in the urine with diabetes. High glucose-induced shedding of ACE2 from proximal tubular c...

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Bibliographic Details
Main Authors: Fengxia eXiao, Joseph eZimpelmann, Dylan eBurger, Chris RJ Kennedy, Richard eHebert, Kevin D Burns
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-06-01
Series:Frontiers in Pharmacology
Subjects:
Kidney
Renin-Angiotensin System
diabetes
PKC
ACE2
ADAM17
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2016.00146/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphar.2016.00146/full

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