Copper-catalyzed dehydrogenative γ-C(sp3)-H amination of saturated ketones for synthesis of polysubstituted anilines
Functionalising ketones at the γ-position is not a trivial synthetic task. Here, the authors developed a copper-catalyzed dehydrogenative γ-amination of saturated ketones, which can then participate in a 3-component coupling reaction to construct polysubstituted anilines.
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2019-08-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-11624-9 |