Copper-catalyzed dehydrogenative γ-C(sp3)-H amination of saturated ketones for synthesis of polysubstituted anilines

Copper-catalyzed dehydrogenative γ-C(sp3)-H amination of saturated ketones for synthesis of polysubstituted anilines

Functionalising ketones at the γ-position is not a trivial synthetic task. Here, the authors developed a copper-catalyzed dehydrogenative γ-amination of saturated ketones, which can then participate in a 3-component coupling reaction to construct polysubstituted anilines.

Bibliographic Details
Main Authors: Rong Hu, Fa-Jie Chen, Xiaofeng Zhang, Min Zhang, Weiping Su
Format: Article
Language:English
Published: Nature Publishing Group 2019-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-11624-9
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spelling doaj-9a216314fdc348f1815594844afa475c2021-05-11T12:24:41ZengNature Publishing GroupNature Communications2041-17232019-08-0110111010.1038/s41467-019-11624-9Copper-catalyzed dehydrogenative γ-C(sp3)-H amination of saturated ketones for synthesis of polysubstituted anilinesRong Hu0Fa-Jie Chen1Xiaofeng Zhang2Min Zhang3Weiping Su4School of Physical Science and Technology, ShanghaiTech UniversityState Key Laboratory of Structural Chemistry, Center for Excellence in Molecular Synthesis, Fujian Institute of Research on the Structure of Matter, Chinese Academy of SciencesState Key Laboratory of Structural Chemistry, Center for Excellence in Molecular Synthesis, Fujian Institute of Research on the Structure of Matter, Chinese Academy of SciencesState Key Laboratory of Structural Chemistry, Center for Excellence in Molecular Synthesis, Fujian Institute of Research on the Structure of Matter, Chinese Academy of SciencesSchool of Physical Science and Technology, ShanghaiTech UniversityFunctionalising ketones at the γ-position is not a trivial synthetic task. Here, the authors developed a copper-catalyzed dehydrogenative γ-amination of saturated ketones, which can then participate in a 3-component coupling reaction to construct polysubstituted anilines.https://doi.org/10.1038/s41467-019-11624-9
collection DOAJ
language English
format Article
sources DOAJ
author Rong Hu
Fa-Jie Chen
Xiaofeng Zhang
Min Zhang
Weiping Su
spellingShingle Rong Hu
Fa-Jie Chen
Xiaofeng Zhang
Min Zhang
Weiping Su
Copper-catalyzed dehydrogenative γ-C(sp3)-H amination of saturated ketones for synthesis of polysubstituted anilines
Nature Communications
author_facet Rong Hu
Fa-Jie Chen
Xiaofeng Zhang
Min Zhang
Weiping Su
author_sort Rong Hu
title Copper-catalyzed dehydrogenative γ-C(sp3)-H amination of saturated ketones for synthesis of polysubstituted anilines
title_short Copper-catalyzed dehydrogenative γ-C(sp3)-H amination of saturated ketones for synthesis of polysubstituted anilines
title_full Copper-catalyzed dehydrogenative γ-C(sp3)-H amination of saturated ketones for synthesis of polysubstituted anilines
title_fullStr Copper-catalyzed dehydrogenative γ-C(sp3)-H amination of saturated ketones for synthesis of polysubstituted anilines
title_full_unstemmed Copper-catalyzed dehydrogenative γ-C(sp3)-H amination of saturated ketones for synthesis of polysubstituted anilines
title_sort copper-catalyzed dehydrogenative γ-c(sp3)-h amination of saturated ketones for synthesis of polysubstituted anilines
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2019-08-01
description Functionalising ketones at the γ-position is not a trivial synthetic task. Here, the authors developed a copper-catalyzed dehydrogenative γ-amination of saturated ketones, which can then participate in a 3-component coupling reaction to construct polysubstituted anilines.
url https://doi.org/10.1038/s41467-019-11624-9
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AT fajiechen coppercatalyzeddehydrogenativegcsp3haminationofsaturatedketonesforsynthesisofpolysubstitutedanilines
AT xiaofengzhang coppercatalyzeddehydrogenativegcsp3haminationofsaturatedketonesforsynthesisofpolysubstitutedanilines
AT minzhang coppercatalyzeddehydrogenativegcsp3haminationofsaturatedketonesforsynthesisofpolysubstitutedanilines
AT weipingsu coppercatalyzeddehydrogenativegcsp3haminationofsaturatedketonesforsynthesisofpolysubstitutedanilines
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