Integrins and Cell Metabolism: An Intimate Relationship Impacting Cancer

Integrins and Cell Metabolism: An Intimate Relationship Impacting Cancer

Integrins are important regulators of cell survival, proliferation, adhesion and migration. Once activated, integrins establish a regulated link between the extracellular matrix and the cytoskeleton. Integrins have well-established functions in cancer, such as in controlling cell survival by engagem...

Full description

Bibliographic Details
Main Authors:	Rehman Ata, Costin N. Antonescu
Format:	Article
Language:	English
Published:	MDPI AG 2017-01-01
Series:	International Journal of Molecular Sciences
Subjects:	AMPK mTOR HIF1 membrane traffic glycosylation hypoxia nutrient deficit cancer metabolism metabolic stress
Online Access:	http://www.mdpi.com/1422-0067/18/1/189

Similar Items

AMPK: Regulation of Metabolic Dynamics in the Context of Autophagy
by: Isaac Tamargo-Gómez, et al.
Published: (2018-11-01)

Insight on Transcriptional Regulation of the Energy Sensing AMPK and Biosynthetic mTOR Pathway Genes
by: Abitha Sukumaran, et al.
Published: (2020-07-01)

ROS signaling under metabolic stress: cross-talk between AMPK and AKT pathway
by: Yang Zhao, et al.
Published: (2017-04-01)

Overexpression of hypoxia-inducible factor and metabolic pathways: possible targets of cancer
by: Davinder Singh, et al.
Published: (2017-11-01)

The Effect of Autophagy on Chronic Intermittent Hypobaric Hypoxia Ameliorating Liver Damage in Metabolic Syndrome Rats
by: Fang Cui, et al.
Published: (2020-01-01)

Taurine Reprograms Mammary-Gland Metabolism and Alleviates Inflammation Induced by Streptococcus uberis in Mice
by: Riguo Lan, et al.
Published: (2021-06-01)

How Tumor Cells Choose Between Epithelial-Mesenchymal Transition and Autophagy to Resist Stress—Therapeutic Implications
by: Fabrizio Marcucci, et al.
Published: (2018-07-01)

Shock Wave Therapy Promotes Cardiomyocyte Autophagy and Survival during Hypoxia
by: Ling Du, et al.
Published: (2017-06-01)

Salidroside attenuates hypoxia-induced pulmonary arterial smooth muscle cell proliferation and apoptosis resistance by upregulating autophagy through the AMPK-mTOR-ULK1 pathway
by: Di Gui, et al.
Published: (2017-12-01)

Acute and chronic heat stress alters the metabolic profile of skeletal muscle in growing swine
by: Won, Samantha Gwai Lan
Published: (2014)

Metformin extends C. elegans lifespan through lysosomal pathway
by: Jie Chen, et al.
Published: (2017-10-01)

Editorial: AMPK and mTOR Beyond Signaling: Emerging Roles in Transcriptional Regulation
by: Étienne Audet-Walsh, et al.
Published: (2021-01-01)

AMP-activated protein kinase (AMPK) as therapeutic target
by: Elżbieta Sarnowska, et al.
Published: (2013-08-01)

Combined metformin-salicylate treatment provides improved anti-tumor activity and enhanced radiotherapy response in prostate cancer; drug synergy at clinically relevant doses
by: Evangelia E. Tsakiridis, et al.
Published: (2021-11-01)

Characterization of mTOR Activity and Metabolic Profile in Pediatric Rhabdomyosarcoma
by: Luca Felkai, et al.
Published: (2020-07-01)

Role of mTOR in Glucose and Lipid Metabolism
by: Zhuo Mao, et al.
Published: (2018-07-01)

Rheostatic Balance of Circadian Rhythm and Autophagy in Metabolism and Disease
by: Xiang Wang, et al.
Published: (2020-11-01)

Inhibition Effect of Chloroquine and Integrin-Linked Kinase Knockdown on Translation in Melanoma Cells
by: Dorota Gil, et al.
Published: (2021-04-01)

SFCE-RAPIRI Phase I Study of Rapamycin Plus Irinotecan: A New Way to Target Intra-Tumor Hypoxia in Pediatric Refractory Cancers
by: Sarah Jannier, et al.
Published: (2020-10-01)

2-Oxonanonoidal Antibiotic Actinolactomycin Inhibits Cancer Progression by Suppressing HIF-1α
by: Jiadong Cheng, et al.
Published: (2019-05-01)

The role of curcumin in disruption of HIF-1α accumulation to alleviate adipose fibrosis via AMPK-mediated mTOR pathway in high-fat diet fed mice
by: Zhixia Qiu, et al.
Published: (2017-06-01)

Dual Roles of the AMP-Activated Protein Kinase Pathway in Angiogenesis
by: Yuanjun Li, et al.
Published: (2019-07-01)

Targeting colorectal cancer cell metabolism through development of cisplatin and metformin nano-cubosomes
by: Mona M. Saber, et al.
Published: (2018-08-01)

Metabolism plays the key roles in Th cells differentiation
by: A. Hosseinzadeh, et al.
Published: (2016-12-01)

The effects of metformin on autophagy
by: Guangli Lu, et al.
Published: (2021-05-01)

Metformin enhances anti-cancer effects of cisplatin in meningioma through AMPK-mTOR signaling pathways
by: Liemei Guo, et al.
Published: (2021-03-01)

Glycolysis inhibition via mTOR suppression is a key step in cardamonin-induced autophagy in SKOV3 cells
by: Daohua Shi, et al.
Published: (2018-12-01)

Metformin – its potential anti-cancer and anti-aging effects
by: Monika Podhorecka, et al.
Published: (2017-03-01)

Dapagliflozin Alleviates Hepatic Steatosis by Restoring Autophagy via the AMPK-mTOR Pathway
by: Liuran Li, et al.
Published: (2021-05-01)

mTOR Complexes as a Nutrient Sensor for Driving Cancer Progression
by: Mio Harachi, et al.
Published: (2018-10-01)

Fucoxanthin, the constituent of Laminaria japonica, triggers AMPK-mediated cytoprotection and autophagy in hepatocytes under oxidative stress
by: Eun Jeong Jang, et al.
Published: (2018-03-01)

In Situ Metabolic Characterisation of Breast Cancer and Its Potential Impact on Therapy
by: Gábor Petővári, et al.
Published: (2020-09-01)

Noni (Morinda citrifolia) Modulates the Hypothalamic Expression of Stress- and Metabolic-Related Genes in Broilers Exposed to Acute Heat Stress
by: Hossein Rajaei-Sharifabadi, et al.
Published: (2017-12-01)

Cellular Metabolic Regulation in the Differentiation and Function of Regulatory T Cells
by: Ye Chen, et al.
Published: (2019-02-01)

mTOR signaling pathway and mTOR inhibitors in cancer: progress and challenges
by: Zhilin Zou, et al.
Published: (2020-03-01)

Second Generation mTOR Inhibitors as a Double-Edged Sword in Malignant Glioma Treatment
by: Dennis Heinzen, et al.
Published: (2019-09-01)

Autophagy as a Vital Therapy Target for Renal Cell Carcinoma
by: Ying-hua He, et al.
Published: (2021-02-01)

BVR-A Deficiency Leads to Autophagy Impairment through the Dysregulation of AMPK/mTOR Axis in the Brain—Implications for Neurodegeneration
by: Chiara Lanzillotta, et al.
Published: (2020-07-01)

Exogenous H2S Protects Against Diabetic Cardiomyopathy by Activating Autophagy via the AMPK/mTOR Pathway
by: Fan Yang, et al.
Published: (2017-10-01)

Metformin as a Treatment Strategy for Sjögren’s Syndrome
by: Joa Kim, et al.
Published: (2021-07-01)

Cannot write session to /tmp/vufind_sessions/sess_ejlfnuf5onfpm8kbpfuf46k3p9