| Summary: | Angiography is a safe technique for the detection of and treatment of
cardiovascular diseases. However, the effects of the technique on the molecular
response of the immune system are yet to be clarified. Toll like receptors (TLRs)
are the important molecule participate in the innate immunity responses and
induction of inflammation. This project was designed to explore the effects of
angiography on the expression of TLR1, TLR2, TLR3 and TLR4. Fifty-five
participants, including three separate groups (without artery stenosis, with one
artery stenosis and more than one artery stenosis), were assessed in this
project. TLR1, TLR2, TLR3 and TLR4 expression levels were evaluated in peripheral
blood immune cells by measuring mRNA before and after angiography using Real-Time
PCR techniques. mRNA levels of TLR1, TLR2 and TLR3 were significantly increased
following angiography. Expression of TLR4 did not change after angiography. Other
criteria also showed no correlation on TLR expression after angiography. TLR4
mRNA levels had a positive correlation with age in the participants without
artery stenosis. Angiography may induce inflammation in subjects without artery
stenosis via up-regulation of TLR1, 2 and 3 which may lead to cardiovascular
diseases related complications.
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