The Bright and the Dark Sides of DNA Repair in Stem Cells
DNA repair is a double-edged sword in stem cells. It protects normal stem cells in both embryonic and adult tissues from genetic damage, thus allowing perpetuation of intact genomes into new tissues. Fast and efficient DNA repair mechanisms have evolved in normal stem and progenitor cells. Upon di...
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| Language: | English |
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Hindawi Limited
2010-01-01
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| Series: | Journal of Biomedicine and Biotechnology |
| Online Access: | http://dx.doi.org/10.1155/2010/845396 |
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doaj-99f1fc7a5d8a4b69bc152ea98913fd3e2020-11-25T02:08:45ZengHindawi LimitedJournal of Biomedicine and Biotechnology1110-72431110-72512010-01-01201010.1155/2010/845396845396The Bright and the Dark Sides of DNA Repair in Stem CellsGuido Frosina0Molecular Mutagenesis & DNA Repair Unit, Istituto Nazionale Ricerca Cancro, 16132 Genova, ItalyDNA repair is a double-edged sword in stem cells. It protects normal stem cells in both embryonic and adult tissues from genetic damage, thus allowing perpetuation of intact genomes into new tissues. Fast and efficient DNA repair mechanisms have evolved in normal stem and progenitor cells. Upon differentiation, a certain degree of somatic mutations becomes more acceptable and, consequently, DNA repair dims. DNA repair turns into a problem when stem cells transform and become cancerous. Transformed stem cells drive growth of a number of tumours (e.g., high grade gliomas) and being particularly resistant to chemo- and radiotherapeutic agents often cause relapses. The contribution of DNA repair to resistance of these tumour-driving cells is the subject of intense research, in order to find novel agents that may sensitize them to chemotherapy and radiotherapy.http://dx.doi.org/10.1155/2010/845396 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Guido Frosina |
| spellingShingle |
Guido Frosina The Bright and the Dark Sides of DNA Repair in Stem Cells Journal of Biomedicine and Biotechnology |
| author_facet |
Guido Frosina |
| author_sort |
Guido Frosina |
| title |
The Bright and the Dark Sides of DNA Repair in Stem Cells |
| title_short |
The Bright and the Dark Sides of DNA Repair in Stem Cells |
| title_full |
The Bright and the Dark Sides of DNA Repair in Stem Cells |
| title_fullStr |
The Bright and the Dark Sides of DNA Repair in Stem Cells |
| title_full_unstemmed |
The Bright and the Dark Sides of DNA Repair in Stem Cells |
| title_sort |
bright and the dark sides of dna repair in stem cells |
| publisher |
Hindawi Limited |
| series |
Journal of Biomedicine and Biotechnology |
| issn |
1110-7243 1110-7251 |
| publishDate |
2010-01-01 |
| description |
DNA repair is a double-edged sword in stem cells. It protects normal stem cells in both embryonic and adult tissues from genetic damage, thus allowing perpetuation of intact genomes into new tissues. Fast and efficient DNA repair mechanisms have evolved in normal stem and progenitor cells. Upon differentiation, a certain degree of somatic mutations becomes more acceptable and, consequently, DNA repair dims. DNA repair turns into a problem when stem cells transform and become cancerous. Transformed stem cells drive growth of a number of tumours (e.g., high grade gliomas) and being particularly resistant to chemo- and radiotherapeutic agents often cause relapses. The contribution of DNA repair to resistance of these tumour-driving cells is the subject of intense research, in order to find novel agents that may sensitize them to chemotherapy and radiotherapy. |
| url |
http://dx.doi.org/10.1155/2010/845396 |
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