Two fast screening methods (GC-MS and TLC-ChEI assay) for rapid evaluation of potential anticholinesterasic indole alkaloids in complex mixtures

Two fast screening methods (GC-MS and TLC-ChEI assay) for rapid evaluation of potential anticholinesterasic indole alkaloids in complex mixtures

The pharmacotherapyfor Alzheimer's disease (AD) includes the use of acetylcholinesterase inhibitors (AChEI). Recent investigations for novel AD therapeutic agents from plants suggested that Tabernaemontana genus is a promising source of novel anticholinesterasic indole alkaloids. In this work t...

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Bibliographic Details
Main Authors:	Ivo J.C. Vieira, Walter L.B. Medeiros, Cecilia S. Monnerat, Jucimar J. Souza, Leda Mathias, Raimundo Braz-Filho, Angelo C. Pinto, Priscila M. Sousa, Claudia M. Rezende, Rosângela De A. Epifanio
Format:	Article
Language:	English
Published:	Academia Brasileira de Ciências 2008-09-01
Series:	Anais da Academia Brasileira de Ciências
Subjects:	Tabernaemontana alcalóides indólicos inibidor colinesterásico cromatografia em camada delgada método de Ellman CG-EM indole alkaloids cholinesterase inhibitor thin-layer chromatography assay Ellman´s method GC-MS
Online Access:	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652008000300003

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