Two fast screening methods (GC-MS and TLC-ChEI assay) for rapid evaluation of potential anticholinesterasic indole alkaloids in complex mixtures

Two fast screening methods (GC-MS and TLC-ChEI assay) for rapid evaluation of potential anticholinesterasic indole alkaloids in complex mixtures

The pharmacotherapyfor Alzheimer's disease (AD) includes the use of acetylcholinesterase inhibitors (AChEI). Recent investigations for novel AD therapeutic agents from plants suggested that Tabernaemontana genus is a promising source of novel anticholinesterasic indole alkaloids. In this work t...

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Bibliographic Details
Main Authors: Ivo J.C. Vieira, Walter L.B. Medeiros, Cecilia S. Monnerat, Jucimar J. Souza, Leda Mathias, Raimundo Braz-Filho, Angelo C. Pinto, Priscila M. Sousa, Claudia M. Rezende, Rosângela De A. Epifanio
Format: Article
Language:English
Published: Academia Brasileira de Ciências 2008-09-01
Series:Anais da Academia Brasileira de Ciências
Subjects:
Tabernaemontana
alcalóides indólicos
inibidor colinesterásico
cromatografia em camada delgada
método de Ellman
CG-EM
indole alkaloids
cholinesterase inhibitor
thin-layer chromatography assay
Ellman´s method
GC-MS
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652008000300003

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652008000300003

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