Management and short-term outcomes of neonates born to mothers with active perinatal SARS-CoV-2 infection

Management and short-term outcomes of neonates born to mothers with active perinatal SARS-CoV-2 infection

Abstract Objective We report here on the management and outcomes of neonates born to mothers with active perinatal SARS-CoV-2 infection. Study design In this prospective study, eligible neonates were enrolled in a database to track in-hospital outcomes and followed up outpatient periodically till 2 ...

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Main Authors: Vineet Lamba, Joan Lien, Jay Desai, Ajay J. Talati
Format: Article
Language:English
Published: BMC 2021-09-01
Series:BMC Pediatrics
Online Access:https://doi.org/10.1186/s12887-021-02872-0
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spelling doaj-99e2a99529e143eb928ddd0baa8dcfad2021-09-19T11:47:03ZengBMCBMC Pediatrics1471-24312021-09-012111810.1186/s12887-021-02872-0Management and short-term outcomes of neonates born to mothers with active perinatal SARS-CoV-2 infectionVineet Lamba0Joan Lien1Jay Desai2Ajay J. Talati3Division of Neonatology, Department of Pediatrics, University of Tennessee Health Sciences CenterDepartment of Pediatrics, University of Tennessee Health Sciences CenterDivision of Neonatology, Department of Pediatrics, University of Tennessee Health Sciences CenterDivision of Neonatology, Department of Pediatrics, University of Tennessee Health Sciences CenterAbstract Objective We report here on the management and outcomes of neonates born to mothers with active perinatal SARS-CoV-2 infection. Study design In this prospective study, eligible neonates were enrolled in a database to track in-hospital outcomes and followed up outpatient periodically till 2 months of age to assess for late onset symptoms of infection. Results From April 2020 to February 2021, 67 mothers with perinatal SARS-CoV-2 infection and 70 at-risk neonates were included. Two neonates (3%) tested positive for SARS-CoV-2 within 48 h of life but remained asymptomatic during hospitalization and at all follow-up periods. Three infants were reported to have a febrile illness in 2 months follow up period, none of which was attributable to SARS-CoV-2. Conclusion Our data supports the emerging evidence which describes a probable low risk of vertical transmission of SARS-CoV-2. We also demonstrate a low risk of post-natal transmission or late-onset symptomatic infection with SARS-CoV-2.https://doi.org/10.1186/s12887-021-02872-0
collection DOAJ
language English
format Article
sources DOAJ
author Vineet Lamba
Joan Lien
Jay Desai
Ajay J. Talati
spellingShingle Vineet Lamba
Joan Lien
Jay Desai
Ajay J. Talati
Management and short-term outcomes of neonates born to mothers with active perinatal SARS-CoV-2 infection
BMC Pediatrics
author_facet Vineet Lamba
Joan Lien
Jay Desai
Ajay J. Talati
author_sort Vineet Lamba
title Management and short-term outcomes of neonates born to mothers with active perinatal SARS-CoV-2 infection
title_short Management and short-term outcomes of neonates born to mothers with active perinatal SARS-CoV-2 infection
title_full Management and short-term outcomes of neonates born to mothers with active perinatal SARS-CoV-2 infection
title_fullStr Management and short-term outcomes of neonates born to mothers with active perinatal SARS-CoV-2 infection
title_full_unstemmed Management and short-term outcomes of neonates born to mothers with active perinatal SARS-CoV-2 infection
title_sort management and short-term outcomes of neonates born to mothers with active perinatal sars-cov-2 infection
publisher BMC
series BMC Pediatrics
issn 1471-2431
publishDate 2021-09-01
description Abstract Objective We report here on the management and outcomes of neonates born to mothers with active perinatal SARS-CoV-2 infection. Study design In this prospective study, eligible neonates were enrolled in a database to track in-hospital outcomes and followed up outpatient periodically till 2 months of age to assess for late onset symptoms of infection. Results From April 2020 to February 2021, 67 mothers with perinatal SARS-CoV-2 infection and 70 at-risk neonates were included. Two neonates (3%) tested positive for SARS-CoV-2 within 48 h of life but remained asymptomatic during hospitalization and at all follow-up periods. Three infants were reported to have a febrile illness in 2 months follow up period, none of which was attributable to SARS-CoV-2. Conclusion Our data supports the emerging evidence which describes a probable low risk of vertical transmission of SARS-CoV-2. We also demonstrate a low risk of post-natal transmission or late-onset symptomatic infection with SARS-CoV-2.
url https://doi.org/10.1186/s12887-021-02872-0
work_keys_str_mv AT vineetlamba managementandshorttermoutcomesofneonatesborntomotherswithactiveperinatalsarscov2infection
AT joanlien managementandshorttermoutcomesofneonatesborntomotherswithactiveperinatalsarscov2infection
AT jaydesai managementandshorttermoutcomesofneonatesborntomotherswithactiveperinatalsarscov2infection
AT ajayjtalati managementandshorttermoutcomesofneonatesborntomotherswithactiveperinatalsarscov2infection
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