Comparison of C‐reactive protein concentrations in dogs with Bordetella bronchiseptica infection and aspiration bronchopneumonia

• Main Authors: Aude Morgane Canonne, Maud Menard, Christelle Maurey, Ghita Benchrekroun, Nina Fernandes Rodrigues, Frédéric Billen, Cecile Clercx
• Format: Article
• Language: English
• Published: Wiley 2021-05-01
• Series: Journal of Veterinary Internal Medicine
• Subjects: aspiration pneumonia; CRP; parenchymal disease; pneumonia; respiratory tract
• Online Access: https://doi.org/10.1111/jvim.16091
• ISSN: 0891-6640; 1939-1676

Abstract Background C‐reactive protein (CRP) is a well‐known acute‐phase protein in dogs that may discriminate bacterial bronchopneumonia from other pulmonary conditions. Bronchopneumonia caused by Bordetella bronchiseptica (Bb) is common but the associated increase in CRP concentration in naturally infected dogs has not been fully explored. Objective To compare CRP concentrations of dogs with Bb infection, with or without radiographic pulmonary lesions, to dogs with aspiration bronchopneumonia (ABP). Animals Sixteen dogs with Bb infection and 36 dogs with ABP. Methods Retrospective study. C‐reactive protein concentrations and thoracic radiographs were available for each dog. Results Eleven dogs with Bb infection had alveolar lesions. In all dogs, CRP concentration was mildly increased (14‐38 mg/L). In the 5 dogs without alveolar lesions, CRP concentration was within the reference range in all but 1 dog, in which it was slightly increased. Median CRP concentration was significantly higher in dogs with alveolar lesions (20 mg/L) compared with dogs without alveolar lesions (5 mg/L; p < .002). In dogs with Bb infection, median duration of clinical signs was not different between dogs with normal CRP concentration and dogs with increased concentration. In dogs with Bb infection either with or without alveolar lessions, median CRP concentration was significantly lower (20 mg/L) than in dogs with ABP (118 mg/L; p < .001). Conclusions and Clinical Importance In contrast to dogs with APB, CRP was not a good marker for the diagnosis of dogs suspected to have bordetellosis. Confirmation of Bb infection still requires lower airway sampling.