A simple open source bioinformatic methodology for initial exploration of GPCR ligands’ agonistic/antagonistic properties

A simple open source bioinformatic methodology for initial exploration of GPCR ligands’ agonistic/antagonistic properties

Abstract Drug development is an arduous procedure, necessitating testing the interaction of a large number of potential candidates with potential interacting (macro)molecules. Therefore, any method which could provide an initial screening of potential candidate drugs might be of interest for the acc...

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Bibliographic Details
Main Authors: Athanasios A. Panagiotopoulos, Christina Papachristofi, Konstantina Kalyvianaki, Panagiotis Malamos, Panayiotis A. Theodoropoulos, George Notas, Theodora Calogeropoulou, Elias Castanas, Marilena Kampa
Format: Article
Language:English
Published: Wiley 2020-08-01
Series:Pharmacology Research & Perspectives
Subjects:
agonist
antagonist
biological activity prediction
docking
GPCR
in silico
Online Access:https://doi.org/10.1002/prp2.600

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