Contributions of Dickkopf‐1 to Obesity‐Induced Bone Loss and Marrow Adiposity

Contributions of Dickkopf‐1 to Obesity‐Induced Bone Loss and Marrow Adiposity

ABSTRACT Low bone strength in overweight individuals is a significant medical problem. One important determinant of mesenchymal stem cell fate into osteoblasts or adipocytes is the Wnt signaling pathway. We recently showed that Dickkopf‐1 (DKK1), a potent Wnt inhibitor, is upregulated in obese mice....

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Bibliographic Details
Main Authors: Juliane Colditz, Ann‐Kristin Picke, Lorenz C. Hofbauer, Martina Rauner
Format: Article
Language:English
Published: Wiley 2020-06-01
Series:JBMR Plus
Subjects:
ADIPOCYTE
BONE MARROW ADIPOSITY
BONE MASS
DICKKOPF‐1
HIGH‐FAT DIET
OSTEOBLAST
Online Access:https://doi.org/10.1002/jbm4.10364

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