Allium sativum aqueous extract prevents potassium dichromate-induced nephrotoxicity and lipid oxidation in rats

• Main Authors: Sergio L. Becerra-Torres, César Soria-Fregozo, Fernando Jaramillo-Juárez, José L. Moreno-Hernández-Duque
• Format: Article
• Language: English
• Published: Academic Association of Pharmaceutical Sciences from Antofagasta (ASOCIFA) 2014-04-01
• Series: Journal of Pharmacy & Pharmacognosy Research
• Subjects: Creatinine; garlic extract; inulin; malondialdehyde; proteinuria; renal clearance; Creatinina; extracto de ajo; inulina; malondialdehído; aclaramiento
• Online Access: http://jppres.com/jppres/pdf/vol2/jppres14.020_2.2.45.pdf

Context: The potassium dichromate (K2Cr2O7) induces nephrotoxicity by oxidative stress mechanisms. Aims: To study the potential protection of an aqueous extract of Allium sativum against the K2Cr2O7-induced nephrotoxicity and lipid oxidation in rats. Methods: Twenty four hours after treatment, biomarkers such as proteinuria, creatinine clearance, malondialdehyde production, specific enzyme activity of gamma glutamyl transpeptidase and alanine aminopeptidase, and renal clearance of para-aminohippuric acid and inulin were measured. Results: The K2Cr2O7 caused significant renal dysfunction, but A. sativum extract prevented this condition by improving all measured biomarkers. Conclusions: A single injection of K2Cr2O7 induced nephrotoxicity in rats, but the supply of an Allium sativum aqueous extract prevented the disorders caused by this metal.