Icariin Protects Bone Marrow Mesenchymal Stem Cells Against Iron Overload Induced Dysfunction Through Mitochondrial Fusion and Fission, PI3K/AKT/mTOR and MAPK Pathways

Icariin Protects Bone Marrow Mesenchymal Stem Cells Against Iron Overload Induced Dysfunction Through Mitochondrial Fusion and Fission, PI3K/AKT/mTOR and MAPK Pathways

Iron overload has been reported to contribute to bone marrow mesenchymal stem cells (BMSCs) damage, but the precise mechanism still remains elusive. Icariin, a major bioactive monomer belonging to flavonoid glucosides isolated from Herba Epimedii, has been shown to protect cells from oxidative stres...

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Bibliographic Details
Main Authors: Xudong Yao, Xingzhi Jing, Jiachao Guo, Kai Sun, Yi Deng, Yong Zhang, Fengjing Guo, Yaping Ye
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-02-01
Series:Frontiers in Pharmacology
Subjects:
iron overload
icariin
bone marrow mesenchymal stem cells
mitochondrial fusion and fission
PI3K/AKT/mTOR pathway
MAPK pathway
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.00163/full

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