Immunologic effects of Verapamil
Calcium channel blockers are used worldwide in CAD, hypertension and arrhythemia. As recent international studies show these drugs in addition to cardiovascular effects have immunosuppressive effects and can prolong graft life in transplanted patients. In a single blind prospective trial we studied...
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Tehran University of Medical Sciences
1998-09-01
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| Series: | Tehran University Medical Journal |
| Online Access: | http://journals.tums.ac.ir/PdfMed.aspx?pdf_med=/upload_files/pdf/5710.pdf&manuscript_id=5710 |
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doaj-99ca7296796f4d1b94cd3c6c7997f1d52020-11-24T22:46:40ZfasTehran University of Medical SciencesTehran University Medical Journal1683-17641735-73221998-09-015663941Immunologic effects of VerapamilMoradmand SSafari FCalcium channel blockers are used worldwide in CAD, hypertension and arrhythemia. As recent international studies show these drugs in addition to cardiovascular effects have immunosuppressive effects and can prolong graft life in transplanted patients. In a single blind prospective trial we studied 30 patients on 120 mg/d Verapamil for at least 3 months compared with 15 patients on placebo. Changes of cell immunity markers were impressive as T suppressor lymphocytes increased and CD4/CD8 ratio decreased significantly compared with placebo (P<0.05). This study confirms that Verapamil reduce cell immunity that may prone human beings to infections and on the other side we can use it in hypertensive patients with organ graft. http://journals.tums.ac.ir/PdfMed.aspx?pdf_med=/upload_files/pdf/5710.pdf&manuscript_id=5710 |
| collection |
DOAJ |
| language |
fas |
| format |
Article |
| sources |
DOAJ |
| author |
Moradmand S Safari F |
| spellingShingle |
Moradmand S Safari F Immunologic effects of Verapamil Tehran University Medical Journal |
| author_facet |
Moradmand S Safari F |
| author_sort |
Moradmand S |
| title |
Immunologic effects of Verapamil |
| title_short |
Immunologic effects of Verapamil |
| title_full |
Immunologic effects of Verapamil |
| title_fullStr |
Immunologic effects of Verapamil |
| title_full_unstemmed |
Immunologic effects of Verapamil |
| title_sort |
immunologic effects of verapamil |
| publisher |
Tehran University of Medical Sciences |
| series |
Tehran University Medical Journal |
| issn |
1683-1764 1735-7322 |
| publishDate |
1998-09-01 |
| description |
Calcium channel blockers are used worldwide in CAD, hypertension and arrhythemia. As recent international studies show these drugs in addition to cardiovascular effects have immunosuppressive effects and can prolong graft life in transplanted patients. In a single blind prospective trial we studied 30 patients on 120 mg/d Verapamil for at least 3 months compared with 15 patients on placebo. Changes of cell immunity markers were impressive as T suppressor lymphocytes increased and CD4/CD8 ratio decreased significantly compared with placebo (P<0.05). This study confirms that Verapamil reduce cell immunity that may prone human beings to infections and on the other side we can use it in hypertensive patients with organ graft. |
| url |
http://journals.tums.ac.ir/PdfMed.aspx?pdf_med=/upload_files/pdf/5710.pdf&manuscript_id=5710 |
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AT moradmands immunologiceffectsofverapamil AT safarif immunologiceffectsofverapamil |
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