Partial Agonist Activity of Neonicotinoids on Rat Nicotinic Receptors: Consequences over Epinephrine Secretion and In Vivo Blood Pressure

Partial Agonist Activity of Neonicotinoids on Rat Nicotinic Receptors: Consequences over Epinephrine Secretion and In Vivo Blood Pressure

Neonicotinoid insecticides are nicotine-derived molecules which exert acute neurotoxic effects over the insect central nervous system by activating nicotinic acetylcholine receptors (nAChRs). However, these receptors are also present in the mammalian central and peripheral nervous system, where the...

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Bibliographic Details
Main Authors: Joohee Park, Antoine Taly, Jennifer Bourreau, Frédéric De Nardi, Claire Legendre, Daniel Henrion, Nathalie C. Guérineau, Christian Legros, César Mattei, Hélène Tricoire-Leignel
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:International Journal of Molecular Sciences
Subjects:
neonicotinoids
acetamiprid
clothianidin
<i>α</i>3<i>β</i>4 nAChR
epinephrine secretion
blood pressure
Online Access:https://www.mdpi.com/1422-0067/22/10/5106

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