Effects of high rosuvastatin doses on hepatocyte mitochondria of hypercholesterolemic mice

Abstract Statins are the cornerstone of therapy for individuals with hyperlipidemia. The aim of this study was to analyze the undesirable effects of mild, moderate and high doses of rosuvastatin in CD-1 male mice who received a cholesterol-rich diet, focusing on the morphological and functional chan...

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Main Authors: Juan C. Díaz-Zagoya, Alejandro Marín-Medina, Alma M. Zetina-Esquivel, Jorge L. Blé-Castillo, Andrés E. Castell-Rodríguez, Isela E. Juárez-Rojop, Rodrigo Miranda-Zamora
Format: Article
Language:English
Published: Nature Publishing Group 2021-08-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-95140-1