A lack of correlation between brain-derived neurotrophic factor serum level and verbal memory performance in healthy Polish population

A lack of correlation between brain-derived neurotrophic factor serum level and verbal memory performance in healthy Polish population

Brain derived neurotrophic factor is considered to be connected with memory and learning through the processes of long term synaptic potentiation and synaptic plasticity. The aim of the study was to examine the relationship between precursor BDNF (proBNDF) and mature BDNF (mBDNF) serum levels and pe...

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Main Authors: Monika eWilkosc, Anita eMarkowska, Ludmila eZajac-Lamparska, Maria eSkibińska, Agnieszka eSzalkowska, Aleksander eAraszkiewicz
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-05-01
Series:Frontiers in Neural Circuits
Subjects:
verbal memory
healthy population
Rey auditory-verbal learning test
serum mBDNF
serum proBDNF
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncir.2016.00039/full
id doaj-99b407c249064a318d6435f9d7d75ae0
record_format Article
spelling doaj-99b407c249064a318d6435f9d7d75ae02020-11-25T00:44:59ZengFrontiers Media S.A.Frontiers in Neural Circuits1662-51102016-05-011010.3389/fncir.2016.00039196923A lack of correlation between brain-derived neurotrophic factor serum level and verbal memory performance in healthy Polish populationMonika eWilkosc0Anita eMarkowska1Ludmila eZajac-Lamparska2Maria eSkibińska3Agnieszka eSzalkowska4Aleksander eAraszkiewicz5Institute of Psychology, Kazimierz Wielki UniversityCollegium Medicum in Bydgoszcz, Nicolaus Copernicus University in TorunInstitute of Psychology, Kazimierz Wielki UniversityPoznan University of Medical SciencesCollegium Medicum in Bydgoszcz, Nicolaus Copernicus University i.., Bydgoszcz, PolandCollegium Medicum in Bydgoszcz, Nicolaus Copernicus University i.., Bydgoszcz, PolandBrain derived neurotrophic factor is considered to be connected with memory and learning through the processes of long term synaptic potentiation and synaptic plasticity. The aim of the study was to examine the relationship between precursor BDNF (proBNDF) and mature BDNF (mBDNF) serum levels and performance on Rey Auditory-Verbal Learning Test (RAVLT) in 150 healthy volunteers. In addition, we have verified the relationships between serum concentration of both forms of BDNF and RAVLT with sociodemographic and lifestyle factors. We found no strong evidence for the correlation of proBDNF and mBDNF serum levels with performance on RAVLT in healthy Polish population in early and middle adulthood. We observed the mBDNF serum concentration to be higher in women compared with men. Moreover, we revealed higher mBDNF level to be connected with lower Body Mass Index (BMI). In turn, the results of RAVLT correlated with sociodemographic and lifestyle factors, such as: age, education, gender, BMI and smoking.http://journal.frontiersin.org/Journal/10.3389/fncir.2016.00039/fullverbal memoryhealthy populationRey auditory-verbal learning testserum mBDNFserum proBDNF
collection DOAJ
language English
format Article
sources DOAJ
author Monika eWilkosc
Anita eMarkowska
Ludmila eZajac-Lamparska
Maria eSkibińska
Agnieszka eSzalkowska
Aleksander eAraszkiewicz
spellingShingle Monika eWilkosc
Anita eMarkowska
Ludmila eZajac-Lamparska
Maria eSkibińska
Agnieszka eSzalkowska
Aleksander eAraszkiewicz
A lack of correlation between brain-derived neurotrophic factor serum level and verbal memory performance in healthy Polish population
Frontiers in Neural Circuits
verbal memory
healthy population
Rey auditory-verbal learning test
serum mBDNF
serum proBDNF
author_facet Monika eWilkosc
Anita eMarkowska
Ludmila eZajac-Lamparska
Maria eSkibińska
Agnieszka eSzalkowska
Aleksander eAraszkiewicz
author_sort Monika eWilkosc
title A lack of correlation between brain-derived neurotrophic factor serum level and verbal memory performance in healthy Polish population
title_short A lack of correlation between brain-derived neurotrophic factor serum level and verbal memory performance in healthy Polish population
title_full A lack of correlation between brain-derived neurotrophic factor serum level and verbal memory performance in healthy Polish population
title_fullStr A lack of correlation between brain-derived neurotrophic factor serum level and verbal memory performance in healthy Polish population
title_full_unstemmed A lack of correlation between brain-derived neurotrophic factor serum level and verbal memory performance in healthy Polish population
title_sort lack of correlation between brain-derived neurotrophic factor serum level and verbal memory performance in healthy polish population
publisher Frontiers Media S.A.
series Frontiers in Neural Circuits
issn 1662-5110
publishDate 2016-05-01
description Brain derived neurotrophic factor is considered to be connected with memory and learning through the processes of long term synaptic potentiation and synaptic plasticity. The aim of the study was to examine the relationship between precursor BDNF (proBNDF) and mature BDNF (mBDNF) serum levels and performance on Rey Auditory-Verbal Learning Test (RAVLT) in 150 healthy volunteers. In addition, we have verified the relationships between serum concentration of both forms of BDNF and RAVLT with sociodemographic and lifestyle factors. We found no strong evidence for the correlation of proBDNF and mBDNF serum levels with performance on RAVLT in healthy Polish population in early and middle adulthood. We observed the mBDNF serum concentration to be higher in women compared with men. Moreover, we revealed higher mBDNF level to be connected with lower Body Mass Index (BMI). In turn, the results of RAVLT correlated with sociodemographic and lifestyle factors, such as: age, education, gender, BMI and smoking.
topic verbal memory
healthy population
Rey auditory-verbal learning test
serum mBDNF
serum proBDNF
url http://journal.frontiersin.org/Journal/10.3389/fncir.2016.00039/full
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