Synthesis and Properties of Gelatin Methacryloyl (GelMA) Hydrogels and Their Recent Applications in Load-Bearing Tissue

Synthesis and Properties of Gelatin Methacryloyl (GelMA) Hydrogels and Their Recent Applications in Load-Bearing Tissue

Photocrosslinked gelatin methacryloyl (GelMA) hydrogels have attracted great concern in the biomedical field because of their good biocompatibility and tunable physicochemical properties. Herein, different approaches to synthesize GelMA were introduced, especially, the typical method using UV light...

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Main Authors: Mingyue Sun, Xiaoting Sun, Ziyuan Wang, Shuyu Guo, Guangjiao Yu, Huazhe Yang
Format: Article
Language:English
Published: MDPI AG 2018-11-01
Series:Polymers
Subjects:
GelMA
photocrosslink
cell culture
load-bearing tissue
Online Access:https://www.mdpi.com/2073-4360/10/11/1290
id doaj-99ab4b8681ab4aebb2bb919b2d3d02ed
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spelling doaj-99ab4b8681ab4aebb2bb919b2d3d02ed2020-11-24T22:58:12ZengMDPI AGPolymers2073-43602018-11-011011129010.3390/polym10111290polym10111290Synthesis and Properties of Gelatin Methacryloyl (GelMA) Hydrogels and Their Recent Applications in Load-Bearing TissueMingyue Sun0Xiaoting Sun1Ziyuan Wang2Shuyu Guo3Guangjiao Yu4Huazhe Yang5School of Fundamental Sciences, China Medical University, Shenyang 110122, ChinaSchool of Fundamental Sciences, China Medical University, Shenyang 110122, ChinaThe Queen’s University of Belfast Joint College, China Medical University, Shenyang 110122, ChinaThe Queen’s University of Belfast Joint College, China Medical University, Shenyang 110122, ChinaThe Queen’s University of Belfast Joint College, China Medical University, Shenyang 110122, ChinaSchool of Fundamental Sciences, China Medical University, Shenyang 110122, ChinaPhotocrosslinked gelatin methacryloyl (GelMA) hydrogels have attracted great concern in the biomedical field because of their good biocompatibility and tunable physicochemical properties. Herein, different approaches to synthesize GelMA were introduced, especially, the typical method using UV light to crosslink the gelatin-methacrylic anhydride (MA) precursor was introduced in detail. In addition, the traditional and cutting-edge technologies to characterize the properties of GelMA hydrogels and GelMA prepolymer were also overviewed and compared. Furthermore, the applications of GelMA hydrogels in cell culture and tissue engineering especially in the load-bearing tissue (bone and cartilage) were summarized, followed by concluding remarks.https://www.mdpi.com/2073-4360/10/11/1290GelMAphotocrosslinkcell cultureload-bearing tissue
collection DOAJ
language English
format Article
sources DOAJ
author Mingyue Sun
Xiaoting Sun
Ziyuan Wang
Shuyu Guo
Guangjiao Yu
Huazhe Yang
spellingShingle Mingyue Sun
Xiaoting Sun
Ziyuan Wang
Shuyu Guo
Guangjiao Yu
Huazhe Yang
Synthesis and Properties of Gelatin Methacryloyl (GelMA) Hydrogels and Their Recent Applications in Load-Bearing Tissue
Polymers
GelMA
photocrosslink
cell culture
load-bearing tissue
author_facet Mingyue Sun
Xiaoting Sun
Ziyuan Wang
Shuyu Guo
Guangjiao Yu
Huazhe Yang
author_sort Mingyue Sun
title Synthesis and Properties of Gelatin Methacryloyl (GelMA) Hydrogels and Their Recent Applications in Load-Bearing Tissue
title_short Synthesis and Properties of Gelatin Methacryloyl (GelMA) Hydrogels and Their Recent Applications in Load-Bearing Tissue
title_full Synthesis and Properties of Gelatin Methacryloyl (GelMA) Hydrogels and Their Recent Applications in Load-Bearing Tissue
title_fullStr Synthesis and Properties of Gelatin Methacryloyl (GelMA) Hydrogels and Their Recent Applications in Load-Bearing Tissue
title_full_unstemmed Synthesis and Properties of Gelatin Methacryloyl (GelMA) Hydrogels and Their Recent Applications in Load-Bearing Tissue
title_sort synthesis and properties of gelatin methacryloyl (gelma) hydrogels and their recent applications in load-bearing tissue
publisher MDPI AG
series Polymers
issn 2073-4360
publishDate 2018-11-01
description Photocrosslinked gelatin methacryloyl (GelMA) hydrogels have attracted great concern in the biomedical field because of their good biocompatibility and tunable physicochemical properties. Herein, different approaches to synthesize GelMA were introduced, especially, the typical method using UV light to crosslink the gelatin-methacrylic anhydride (MA) precursor was introduced in detail. In addition, the traditional and cutting-edge technologies to characterize the properties of GelMA hydrogels and GelMA prepolymer were also overviewed and compared. Furthermore, the applications of GelMA hydrogels in cell culture and tissue engineering especially in the load-bearing tissue (bone and cartilage) were summarized, followed by concluding remarks.
topic GelMA
photocrosslink
cell culture
load-bearing tissue
url https://www.mdpi.com/2073-4360/10/11/1290
work_keys_str_mv AT mingyuesun synthesisandpropertiesofgelatinmethacryloylgelmahydrogelsandtheirrecentapplicationsinloadbearingtissue
AT xiaotingsun synthesisandpropertiesofgelatinmethacryloylgelmahydrogelsandtheirrecentapplicationsinloadbearingtissue
AT ziyuanwang synthesisandpropertiesofgelatinmethacryloylgelmahydrogelsandtheirrecentapplicationsinloadbearingtissue
AT shuyuguo synthesisandpropertiesofgelatinmethacryloylgelmahydrogelsandtheirrecentapplicationsinloadbearingtissue
AT guangjiaoyu synthesisandpropertiesofgelatinmethacryloylgelmahydrogelsandtheirrecentapplicationsinloadbearingtissue
AT huazheyang synthesisandpropertiesofgelatinmethacryloylgelmahydrogelsandtheirrecentapplicationsinloadbearingtissue
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