Downregulation of CD45 Signaling in COVID-19 Patients Is Reversed by C24D, a Novel CD45 Targeting Peptide

Downregulation of CD45 Signaling in COVID-19 Patients Is Reversed by C24D, a Novel CD45 Targeting Peptide

CD45, the predominant transmembrane tyrosine phosphatase in leukocytes, is required for the efficient induction of T cell receptor signaling and activation. We recently reported that the CD45-intracellular signals in peripheral blood mononuclear cells (PBMCs) of triple negative breast cancer (TNBC)...

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Bibliographic Details
Main Authors: Danny Alon, Yossi Paitan, Eyal Robinson, Nirit Ganor, Julia Lipovetsky, Rinat Yerushalmi, Cyrille J. Cohen, Annat Raiter
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Medicine
Subjects:
CD45
COVID-19
PBMC
Src family of tyrosine kinases
immunosuppression
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2021.675963/full

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