DETERMINAÇÃO RÁPIDA E SIMULTÂNEA DE PROPIFENAZONA, PARACETAMOL E CAFEÍNA UTILIZANDO ANÁLISE POR INJEÇÃO EM BATELADA COM DETECÇÃO AMPEROMÉTRICA

• Main Authors: Weberson Pereira Silva, Luiz André Juvêncio Silva, Rodrigo Alejandro Abarza Muñoz, Eduardo Mathias Richter
• Format: Article
• Language: English
• Published: Sociedade Brasileira de Química
• Series: Química Nova
• Subjects: boron doped diamond electrode (BDDE); multiple-pulse amperometric detection; portable electrochemical method; pharmaceutical
• Online Access: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422017001001180&lng=en&tlng=en

A fast and simple procedure for simultaneous determination of propyphenazone (PRO), paracetamol (PAR) and caffeine (CAF) was performed using batch injection analysis with multiple pulse amperometric detection (BIA-MPA). Three potentials pulses were selected for the analysis: +0.90 V/50 ms: only PAR was oxidized; +1.20 V/50 ms: oxidation of PAR and PRO without the interference of CAF; +1.60 V/50 ms: oxidation of the three compounds (PAR, PRO and CAF). The sample aliquot (150 µL) was directly injected onto the boron-doped diamond (BDD) electrode immersed in a BIA cell. The analytical characteristics of the proposed method include high analytical frequency (75 injections per hour), good stability (RSD < 3.9%; n = 10), and low detection limits (0.3, 0.2 and 0.1 mg L−1 for PRO, PAR and CAF, respectively). The proposed method yielded similar results to those obtained by liquid chromatography at a 95% confidence level.