A Green, Scalable, and Catalyst-Free One-Minute Synthesis of Quinoxalines

A highly efficient and catalyst-free protocol is reported for the synthesis of quinoxalines via the classical cyclocondensation reaction between aryldiamines and dicarbonyl compounds. Remarkably simple and green reaction conditions employing methanol as solvent afforded medium to excellent yield of...

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Main Authors:	Vijayaragavan Elumalai, Jørn H. Hansen
Format:	Article
Language:	English
Published:	Georg Thieme Verlag KG 2021-01-01
Series:	SynOpen
Subjects:	quinoxaline diamine condensation diketone green
Online Access:	http://www.thieme-connect.de/DOI/DOI?10.1055/s-0040-1706021

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spelling	doaj-9981e4efce364b7ab0bf6681ce7cd7b82021-02-11T00:03:29ZengGeorg Thieme Verlag KGSynOpen2509-93962021-01-010501434810.1055/s-0040-1706021A Green, Scalable, and Catalyst-Free One-Minute Synthesis of QuinoxalinesVijayaragavan ElumalaiJørn H. HansenA highly efficient and catalyst-free protocol is reported for the synthesis of quinoxalines via the classical cyclocondensation reaction between aryldiamines and dicarbonyl compounds. Remarkably simple and green reaction conditions employing methanol as solvent afforded medium to excellent yield of quinoxalines after only one-minute reaction time at ambient temperature. The conditions allow at least 10 gram scale synthesis of quinoxalines and should be a preferred starting point for optimization and method of choice for applications in the synthetic community.http://www.thieme-connect.de/DOI/DOI?10.1055/s-0040-1706021quinoxalinediaminecondensationdiketonegreen
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Vijayaragavan Elumalai Jørn H. Hansen
spellingShingle	Vijayaragavan Elumalai Jørn H. Hansen A Green, Scalable, and Catalyst-Free One-Minute Synthesis of Quinoxalines SynOpen quinoxaline diamine condensation diketone green
author_facet	Vijayaragavan Elumalai Jørn H. Hansen
author_sort	Vijayaragavan Elumalai
title	A Green, Scalable, and Catalyst-Free One-Minute Synthesis of Quinoxalines
title_short	A Green, Scalable, and Catalyst-Free One-Minute Synthesis of Quinoxalines
title_full	A Green, Scalable, and Catalyst-Free One-Minute Synthesis of Quinoxalines
title_fullStr	A Green, Scalable, and Catalyst-Free One-Minute Synthesis of Quinoxalines
title_full_unstemmed	A Green, Scalable, and Catalyst-Free One-Minute Synthesis of Quinoxalines
title_sort	green, scalable, and catalyst-free one-minute synthesis of quinoxalines
publisher	Georg Thieme Verlag KG
series	SynOpen
issn	2509-9396
publishDate	2021-01-01
description	A highly efficient and catalyst-free protocol is reported for the synthesis of quinoxalines via the classical cyclocondensation reaction between aryldiamines and dicarbonyl compounds. Remarkably simple and green reaction conditions employing methanol as solvent afforded medium to excellent yield of quinoxalines after only one-minute reaction time at ambient temperature. The conditions allow at least 10 gram scale synthesis of quinoxalines and should be a preferred starting point for optimization and method of choice for applications in the synthetic community.
topic	quinoxaline diamine condensation diketone green
url	http://www.thieme-connect.de/DOI/DOI?10.1055/s-0040-1706021
work_keys_str_mv	AT vijayaragavanelumalai agreenscalableandcatalystfreeoneminutesynthesisofquinoxalines AT jørnhhansen agreenscalableandcatalystfreeoneminutesynthesisofquinoxalines AT vijayaragavanelumalai greenscalableandcatalystfreeoneminutesynthesisofquinoxalines AT jørnhhansen greenscalableandcatalystfreeoneminutesynthesisofquinoxalines
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A Green, Scalable, and Catalyst-Free One-Minute Synthesis of Quinoxalines

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