Senyawa Aktif Antiinflamasi dari Kulit Batang Pasak Bumi (Eurycoma longifolia Jack)

• Main Authors: Ari Widiyantoro, Indri Kusharyanti, Lia Destiarti, Elvi Rusmiyanto Pancaning Wardoyo
• Format: Article
• Language: Indonesian
• Published: Universitas Islam Indonesia 2012-02-01
• Series: Eksakta: Jurnal Ilmu-Ilmu MIPA
• Online Access: http://journal.uii.ac.id/index.php/Eksakta/article/view/2534

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mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin:0in; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:"Times New Roman"; mso-bidi-theme-font:minor-bidi;} </style> <![endif]--> <p class="MsoNormal" style="text-align:justify;text-indent:.5in;mso-layout-grid-align: none;text-autospace:none"><span style="font-size:11.0pt;mso-ansi-language: IN" lang="IN">Pasak bumi <em style="mso-bidi-font-style:normal">(Eurycoma longifolia</em> Jack) merupakan salah satu famili Simaroubaceae yang mengandung senyawa kimia dengan aktivitas biologik yang potensial</span><span style="font-size: 11.0pt;mso-ansi-language:FI" lang="FI">.</span><span style="font-size:11.0pt; mso-ansi-language:IN" lang="IN">Penggunaannya di masyarakat selama ini hanya terbatas sebagai aprodisiaka, namun beberapa penelitian menunjukkan ditemukannya senyawa kimia dengan aktivitas sebagai antimalaria, antikanker dan antioksidan. Penelitian ini mengungkapkan adanya senyawa kimia yang bersifat antiinflamasi dengan tinjauan reduksi radang pada kaki tikus yang terinduksi karagenan. Hasil penelitian diperoleh suatu senyawa quassinoid yang bersifat antiinflamasi yaitu eurycomaosida, namun aktivitasnya lebih rendah dibanding indometasin sebagai kontrol positif.</span></p> <p class="MsoNormal" style="text-align:justify;mso-layout-grid-align:none; text-autospace:none"><strong style="mso-bidi-font-weight:normal"><span style="font-size:11.0pt;mso-ansi-language:FI" lang="FI"> </span></strong></p> <p class="MsoNormal" style="text-align:justify;mso-layout-grid-align:none; text-autospace:none"><strong style="mso-bidi-font-weight:normal"><span style="font-size:11.0pt;mso-ansi-language:FI" lang="FI">Kata Kunci :</span></strong><span style="font-size:11.0pt;mso-ansi-language:FI" lang="FI"> </span><em style="mso-bidi-font-style:normal"><span style="font-size:11.0pt; mso-ansi-language:IN" lang="IN">Eurycoma longifolia</span></em><span style="font-size:11.0pt;mso-ansi-language:IN" lang="IN"> Jack, antiinflamasi, udema, karagenan, quassinoid</span></p>