Dynamic ubiquitylation of Sox2 regulates proteostasis and governs neural progenitor cell differentiation

Dynamic ubiquitylation of Sox2 regulates proteostasis and governs neural progenitor cell differentiation

Sox2 regulates pluripotency in neural progenitor cells (NPC) but how protein stability affects this is unclear. Here, the authors identify changes in ubiquitylation of Sox2 (by CUL4A-DET1-COP1 ligase and OTUD7B deubiquitylase) as controlling protein stability and so the differentiation state of NPCs...

Full description

Bibliographic Details
Main Authors: Chun-Ping Cui, Yuan Zhang, Chanjuan Wang, Fang Yuan, Hongchang Li, Yuying Yao, Yuhan Chen, Chunnan Li, Wenyi Wei, Cui Hua Liu, Fuchu He, Yan Liu, Lingqiang Zhang
Format: Article
Language:English
Published: Nature Publishing Group 2018-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-07025-z

Internet

https://doi.org/10.1038/s41467-018-07025-z

Similar Items