Molecular and functional heterogeneity of IL-10-producing CD4 + T cells
Tr1 cells are considered an immunosuppressive CD4 T cell population producing IL-10. Here the authors show that IL-10 is insufficient for Tr1 immunosuppression, define surface markers and transcriptional program of the immunosuppressive subset within Tr1, and reveal its deficiency in patients with I...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2018-12-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-07581-4 |
| id |
doaj-9965d7bfb0694a05899ad6316109497d |
|---|---|
| record_format |
Article |
| spelling |
doaj-9965d7bfb0694a05899ad6316109497d2021-05-11T09:49:23ZengNature Publishing GroupNature Communications2041-17232018-12-019111410.1038/s41467-018-07581-4Molecular and functional heterogeneity of IL-10-producing CD4 + T cellsLeonie Brockmann0Shiwa Soukou1Babett Steglich2Paulo Czarnewski3Lilan Zhao4Sandra Wende5Tanja Bedke6Can Ergen7Carolin Manthey8Theodora Agalioti9Maria Geffken10Oliver Seiz11Sara M. Parigi12Chiara Sorini13Jens Geginat14Keishi Fujio15Thomas Jacobs16Thomas Roesch17Jacob R. Izbicki18Ansgar W. Lohse19Richard A. Flavell20Christian Krebs21Jan-Ake Gustafsson22Per Antonson23Maria Grazia Roncarolo24Eduardo J. Villablanca25Nicola Gagliani26Samuel Huber27I. Department of Medicine, University Medical Center Hamburg-EppendorfI. Department of Medicine, University Medical Center Hamburg-EppendorfI. Department of Medicine, University Medical Center Hamburg-EppendorfImmunology and Allergy Unit, Department of Medicine, Solna, Karolinska Institute and University HospitalDepartment of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-EppendorfI. Department of Medicine, University Medical Center Hamburg-EppendorfI. Department of Medicine, University Medical Center Hamburg-EppendorfI. Department of Medicine, University Medical Center Hamburg-EppendorfI. Department of Medicine, University Medical Center Hamburg-EppendorfDepartment of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-EppendorfInstitute of Transfusion Medicine, University Medical Center Hamburg-EppendorfI. Department of Medicine, University Medical Center Hamburg-EppendorfImmunology and Allergy Unit, Department of Medicine, Solna, Karolinska Institute and University HospitalImmunology and Allergy Unit, Department of Medicine, Solna, Karolinska Institute and University HospitalINGM-National Institute of Molecular Genetics “Romeo ed Enrica Invernizzi”Department of Allergy and Rheumatology, Graduate School of Medicine, The University of TokyoDepartment of Immunology, Bernhard-Nocht-Institute of Tropical MedicineDepartment for Interdisciplinary Endoscopy, University Medical Center Hamburg-EppendorfDepartment of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-EppendorfI. Department of Medicine, University Medical Center Hamburg-EppendorfDepartment of Immunobiology, School of Medicine, Yale UniversityIII. Department of Medicine, University Medical Center Hamburg-EppendorfDepartment of Biosciences and Nutrition, Karolinska InstitutetDepartment of Biosciences and Nutrition, Karolinska InstitutetDivision of Stem Cell Transplantation and Regenerative Medicine, Department of Pediatrics, ISCBRM, Stanford School of MedicineImmunology and Allergy Unit, Department of Medicine, Solna, Karolinska Institute and University HospitalI. Department of Medicine, University Medical Center Hamburg-EppendorfI. Department of Medicine, University Medical Center Hamburg-EppendorfTr1 cells are considered an immunosuppressive CD4 T cell population producing IL-10. Here the authors show that IL-10 is insufficient for Tr1 immunosuppression, define surface markers and transcriptional program of the immunosuppressive subset within Tr1, and reveal its deficiency in patients with IBD.https://doi.org/10.1038/s41467-018-07581-4 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Leonie Brockmann Shiwa Soukou Babett Steglich Paulo Czarnewski Lilan Zhao Sandra Wende Tanja Bedke Can Ergen Carolin Manthey Theodora Agalioti Maria Geffken Oliver Seiz Sara M. Parigi Chiara Sorini Jens Geginat Keishi Fujio Thomas Jacobs Thomas Roesch Jacob R. Izbicki Ansgar W. Lohse Richard A. Flavell Christian Krebs Jan-Ake Gustafsson Per Antonson Maria Grazia Roncarolo Eduardo J. Villablanca Nicola Gagliani Samuel Huber |
| spellingShingle |
Leonie Brockmann Shiwa Soukou Babett Steglich Paulo Czarnewski Lilan Zhao Sandra Wende Tanja Bedke Can Ergen Carolin Manthey Theodora Agalioti Maria Geffken Oliver Seiz Sara M. Parigi Chiara Sorini Jens Geginat Keishi Fujio Thomas Jacobs Thomas Roesch Jacob R. Izbicki Ansgar W. Lohse Richard A. Flavell Christian Krebs Jan-Ake Gustafsson Per Antonson Maria Grazia Roncarolo Eduardo J. Villablanca Nicola Gagliani Samuel Huber Molecular and functional heterogeneity of IL-10-producing CD4 + T cells Nature Communications |
| author_facet |
Leonie Brockmann Shiwa Soukou Babett Steglich Paulo Czarnewski Lilan Zhao Sandra Wende Tanja Bedke Can Ergen Carolin Manthey Theodora Agalioti Maria Geffken Oliver Seiz Sara M. Parigi Chiara Sorini Jens Geginat Keishi Fujio Thomas Jacobs Thomas Roesch Jacob R. Izbicki Ansgar W. Lohse Richard A. Flavell Christian Krebs Jan-Ake Gustafsson Per Antonson Maria Grazia Roncarolo Eduardo J. Villablanca Nicola Gagliani Samuel Huber |
| author_sort |
Leonie Brockmann |
| title |
Molecular and functional heterogeneity of IL-10-producing CD4 + T cells |
| title_short |
Molecular and functional heterogeneity of IL-10-producing CD4 + T cells |
| title_full |
Molecular and functional heterogeneity of IL-10-producing CD4 + T cells |
| title_fullStr |
Molecular and functional heterogeneity of IL-10-producing CD4 + T cells |
| title_full_unstemmed |
Molecular and functional heterogeneity of IL-10-producing CD4 + T cells |
| title_sort |
molecular and functional heterogeneity of il-10-producing cd4 + t cells |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2018-12-01 |
| description |
Tr1 cells are considered an immunosuppressive CD4 T cell population producing IL-10. Here the authors show that IL-10 is insufficient for Tr1 immunosuppression, define surface markers and transcriptional program of the immunosuppressive subset within Tr1, and reveal its deficiency in patients with IBD. |
| url |
https://doi.org/10.1038/s41467-018-07581-4 |
| work_keys_str_mv |
AT leoniebrockmann molecularandfunctionalheterogeneityofil10producingcd4tcells AT shiwasoukou molecularandfunctionalheterogeneityofil10producingcd4tcells AT babettsteglich molecularandfunctionalheterogeneityofil10producingcd4tcells AT pauloczarnewski molecularandfunctionalheterogeneityofil10producingcd4tcells AT lilanzhao molecularandfunctionalheterogeneityofil10producingcd4tcells AT sandrawende molecularandfunctionalheterogeneityofil10producingcd4tcells AT tanjabedke molecularandfunctionalheterogeneityofil10producingcd4tcells AT canergen molecularandfunctionalheterogeneityofil10producingcd4tcells AT carolinmanthey molecularandfunctionalheterogeneityofil10producingcd4tcells AT theodoraagalioti molecularandfunctionalheterogeneityofil10producingcd4tcells AT mariageffken molecularandfunctionalheterogeneityofil10producingcd4tcells AT oliverseiz molecularandfunctionalheterogeneityofil10producingcd4tcells AT saramparigi molecularandfunctionalheterogeneityofil10producingcd4tcells AT chiarasorini molecularandfunctionalheterogeneityofil10producingcd4tcells AT jensgeginat molecularandfunctionalheterogeneityofil10producingcd4tcells AT keishifujio molecularandfunctionalheterogeneityofil10producingcd4tcells AT thomasjacobs molecularandfunctionalheterogeneityofil10producingcd4tcells AT thomasroesch molecularandfunctionalheterogeneityofil10producingcd4tcells AT jacobrizbicki molecularandfunctionalheterogeneityofil10producingcd4tcells AT ansgarwlohse molecularandfunctionalheterogeneityofil10producingcd4tcells AT richardaflavell molecularandfunctionalheterogeneityofil10producingcd4tcells AT christiankrebs molecularandfunctionalheterogeneityofil10producingcd4tcells AT janakegustafsson molecularandfunctionalheterogeneityofil10producingcd4tcells AT perantonson molecularandfunctionalheterogeneityofil10producingcd4tcells AT mariagraziaroncarolo molecularandfunctionalheterogeneityofil10producingcd4tcells AT eduardojvillablanca molecularandfunctionalheterogeneityofil10producingcd4tcells AT nicolagagliani molecularandfunctionalheterogeneityofil10producingcd4tcells AT samuelhuber molecularandfunctionalheterogeneityofil10producingcd4tcells |
| _version_ |
1721449188809506816 |