Implementation of Pharmacokinetic and Pharmacodynamic Strategies in Early Research Phases of Drug Discovery and Development at Novartis Institute of Biomedical Research

Implementation of Pharmacokinetic and Pharmacodynamic Strategies in Early Research Phases of Drug Discovery and Development at Novartis Institute of Biomedical Research

Characterizing the relationship between the pharmacokinetics (PK, concentration vs. time) and pharmacodynamics (PD, effect vs. time) is an important tool in the discovery and development of new drugs in the pharmaceutical industry. The purpose of this publication is to serve as a guide for drug disc...

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Bibliographic Details
Main Authors: Tove eTuntland, Brian eEthell, Richard eZang, Monish eJain, Takatoshi eKosaka, Francesca eBlasco, Ty eGould, Keith eHoffmaster
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-07-01
Series:Frontiers in Pharmacology
Subjects:
Drug Discovery
pharmacokinetics
Pharmacodynamics
DMPK
PK-PD modeling
Novartis
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2014.00174/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphar.2014.00174/full

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