An immune-centric exploration of BRCA1 and BRCA2 germline mutation related breast and ovarian cancers

An immune-centric exploration of BRCA1 and BRCA2 germline mutation related breast and ovarian cancers

Abstract Background BRCA1/2 germline mutation related cancers are candidates for new immune therapeutic interventions. This study was a hypothesis generating exploration of genomic data collected at diagnosis for 19 patients. The prominent tumor mutation burden (TMB) in hereditary breast and ovarian...

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Bibliographic Details
Main Authors: Ewa Przybytkowski, Thomas Davis, Abdelrahman Hosny, Julia Eismann, Ursula A. Matulonis, Gerburg M. Wulf, Sheida Nabavi
Format: Article
Language:English
Published: BMC 2020-03-01
Series:BMC Cancer
Subjects:
BRCA1
BRCA2
Breast cancer
Ovarian cancer
Tumor mutation burden
Homologous recombination deficiency
Online Access:http://link.springer.com/article/10.1186/s12885-020-6605-1

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