Thyroxine Alleviates Energy Failure, Prevents Myocardial Cell Apoptosis, and Protects against Doxorubicin-Induced Cardiac Injury and Cardiac Dysfunction via the LKB1/AMPK/mTOR Axis in Mice

Thyroxine Alleviates Energy Failure, Prevents Myocardial Cell Apoptosis, and Protects against Doxorubicin-Induced Cardiac Injury and Cardiac Dysfunction via the LKB1/AMPK/mTOR Axis in Mice

Background. Previous studies have demonstrated that energy failure is closely associated with cardiac injury. Doxorubicin (DOX) is a commonly used clinical chemotherapy drug that can mediate cardiac injury through a variety of mechanisms. Thyroxine is well known to play a critical role in energy gen...

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Bibliographic Details
Main Authors: Yuan Wang, Shan Zhu, Hongtao Liu, Wen Wei, Yi Tu, Chuang Chen, Junlong Song, Juanjuan Li, Shengrong Sun, Changhua Wang, Zhiliang Xu
Format: Article
Language:English
Published: Hindawi Limited 2019-01-01
Series:Disease Markers
Online Access:http://dx.doi.org/10.1155/2019/7420196

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