A strategy for designing voriconazole dosage regimens to prevent invasive pulmonary aspergillosis based on a cellular pharmacokinetics/pharmacodynamics model

A strategy for designing voriconazole dosage regimens to prevent invasive pulmonary aspergillosis based on a cellular pharmacokinetics/pharmacodynamics model

Abstract Background Invasive pulmonary aspergillosis (IPA) is a life-threatening disease in immunosuppressed patients. Voriconazole is commonly used to prevent and treat IPA in the clinic, but the optimal prophylactic antifungal regimen is unknown. The objective of this study was to clarify the mech...

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Bibliographic Details
Main Authors: Taotao Wang, Tao Zhang, Ti Meng, Ying Li, Lu Chen, Qianting Yang, Haiyan Dong, Jin’e Lei, Limei Chen, Yalin Dong
Format: Article
Language:English
Published: BMC 2018-06-01
Series:Journal of Translational Medicine
Subjects:
Voriconazole
Invasive pulmonary aspergillosis
Prophylactic antifungal regimen
Monte Carlo simulation
Cellular pharmacodynamic/pharmacodynamic
Online Access:http://link.springer.com/article/10.1186/s12967-018-1533-4

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http://link.springer.com/article/10.1186/s12967-018-1533-4

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