Participation of L-Lactate and Its Receptor HCAR1/GPR81 in Neurovisual Development

Participation of L-Lactate and Its Receptor HCAR1/GPR81 in Neurovisual Development

During the development of the retina and the nervous system, high levels of energy are required by the axons of retinal ganglion cells (RGCs) to grow towards their brain targets. This energy demand leads to an increase of glycolysis and L-lactate concentrations in the retina. L-lactate is known to b...

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Bibliographic Details
Main Authors: Samuel Laroche, Aurélie Stil, Philippe Germain, Hosni Cherif, Sylvain Chemtob, Jean-François Bouchard
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Cells
Subjects:
lactate
GPR81
HCAR1
retinal ganglion cells
growth cone
dLGN
Online Access:https://www.mdpi.com/2073-4409/10/7/1640

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