Connective Tissue Growth Factor Is Overexpressed in Explant Lung Tissue and Broncho-Alveolar Lavage in Transplant-Related Pulmonary Fibrosis

Connective Tissue Growth Factor Is Overexpressed in Explant Lung Tissue and Broncho-Alveolar Lavage in Transplant-Related Pulmonary Fibrosis

BackgroundConnective tissue growth factor (CTGF) is an important mediator in several fibrotic diseases, including lung fibrosis. We investigated CTGF-expression in chronic lung allograft dysfunction (CLAD) and pulmonary graft-versus-host disease (GVHD).Materials and MethodsCTGF expression was assess...

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Main Authors: Arno Vanstapel, Roel Goldschmeding, Roel Broekhuizen, Tri Nguyen, Annelore Sacreas, Janne Kaes, Tobias Heigl, Stijn E. Verleden, Alexandra De Zutter, Geert Verleden, Birgit Weynand, Erik Verbeken, Laurens J. Ceulemans, Dirk E. Van Raemdonck, Arne P. Neyrinck, Helene M. Schoemans, Bart M. Vanaudenaerde, Robin Vos
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Immunology
Subjects:
GVHD
RAS
BOS
lung transplantation
fibrosis
CTGF
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.661761/full

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