Conditionally immortalized mouse embryonic fibroblasts retain proliferative activity without compromising multipotent differentiation potential.

Conditionally immortalized mouse embryonic fibroblasts retain proliferative activity without compromising multipotent differentiation potential.

Mesenchymal stem cells (MSCs) are multipotent cells which reside in many tissues and can give rise to multiple lineages including bone, cartilage and adipose. Although MSCs have attracted significant attention for basic and translational research, primary MSCs have limited life span in culture which...

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Main Authors: Enyi Huang, Yang Bi, Wei Jiang, Xiaoji Luo, Ke Yang, Jian-Li Gao, Yanhong Gao, Qing Luo, Qiong Shi, Stephanie H Kim, Xing Liu, Mi Li, Ning Hu, Hong Liu, Jing Cui, Wenwen Zhang, Ruidong Li, Xiang Chen, Jikun Shen, Yuhan Kong, Jiye Zhang, Jinhua Wang, Jinyong Luo, Bai-Cheng He, Huicong Wang, Russell R Reid, Hue H Luu, Rex C Haydon, Li Yang, Tong-Chuan He
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3285668?pdf=render

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