Nuclear Exosome Targeting Complex Core Factor Zcchc8 Regulates the Degradation of LINE1 RNA in Early Embryos and Embryonic Stem Cells

Nuclear Exosome Targeting Complex Core Factor Zcchc8 Regulates the Degradation of LINE1 RNA in Early Embryos and Embryonic Stem Cells

Summary: The nuclear exosome targeting (NEXT) complex is responsible for specific nuclear RNA degradation in mammalian cells. However, its function in development remains unknown. Here, we find that the depletion of a central factor of the NEXT complex, Zcchc8, in mouse results in developmental defe...

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Bibliographic Details
Main Authors: You Wu, Wenqiang Liu, Jiayu Chen, Shuaitong Liu, Mingzhu Wang, Lei Yang, Chuan Chen, Meijie Qi, Yiwen Xu, Zhibin Qiao, Rushuang Yan, Xiaochen Kou, Yanhong Zhao, Bin Shen, Jiqing Yin, Hong Wang, Yawei Gao, Shaorong Gao
Format: Article
Language:English
Published: Elsevier 2019-11-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124719313695

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