Nonepileptic seizures under levetiracetam therapy: a case report of forced normalization process

Francesca Anzellotti, Raffaella Franciotti, Holta Zhuzhuni, Aurelio D'Amico, Astrid Thomas, Marco Onofrj Department of Neuroscience and Imaging, Aging Research Centre, Gabriele d'Annunzio University Foundation, Gabriele d'Annunzio University, Chieti, Italy Abstract: Nonepil...

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Main Authors: Anzellotti F, Franciotti R, Zhuzhuni H, D’Amico A, Thomas A, Onofrj M
Format: Article
Language:English
Published: Dove Medical Press 2014-05-01
Series:Neuropsychiatric Disease and Treatment
Online Access:http://www.dovepress.com/nonepileptic-seizures-under-levetiracetam-therapy-a-case-report-of-for-a16991
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spelling doaj-991872ab1eca49f6af1832673493dff82020-11-24T21:23:40ZengDove Medical PressNeuropsychiatric Disease and Treatment1178-20212014-05-012014default95996416991Nonepileptic seizures under levetiracetam therapy: a case report of forced normalization processAnzellotti FFranciotti RZhuzhuni HD’Amico AThomas AOnofrj M Francesca Anzellotti, Raffaella Franciotti, Holta Zhuzhuni, Aurelio D'Amico, Astrid Thomas, Marco Onofrj Department of Neuroscience and Imaging, Aging Research Centre, Gabriele d'Annunzio University Foundation, Gabriele d'Annunzio University, Chieti, Italy Abstract: Nonepileptic seizures (NES) apparently look like epileptic seizures, but are not associated with ictal electrical discharges in the brain. NES constitute one of the most important differential diagnoses of epilepsy. They have been recognized as a distinctive clinical phenomenon for centuries, and video/electroencephalogram monitoring has allowed clinicians to make near-certain diagnoses. NES are supposedly unrelated to organic brain lesions, and despite the preponderance of a psychiatric/psychological context, they may have an iatrogenic origin. We report a patient with NES precipitated by levetiracetam therapy; in this case, NES was observed during the disappearance of epileptiform discharges from the routine video/electroencephalogram. We discuss the possible mechanisms underlying NES with regard to alternative psychoses associated with the phenomenon of the forced normalization process. Keywords: nonepileptic seizures, forced normalization, levetiracetam, behavioral side effectshttp://www.dovepress.com/nonepileptic-seizures-under-levetiracetam-therapy-a-case-report-of-for-a16991
collection DOAJ
language English
format Article
sources DOAJ
author Anzellotti F
Franciotti R
Zhuzhuni H
D’Amico A
Thomas A
Onofrj M
spellingShingle Anzellotti F
Franciotti R
Zhuzhuni H
D’Amico A
Thomas A
Onofrj M
Nonepileptic seizures under levetiracetam therapy: a case report of forced normalization process
Neuropsychiatric Disease and Treatment
author_facet Anzellotti F
Franciotti R
Zhuzhuni H
D’Amico A
Thomas A
Onofrj M
author_sort Anzellotti F
title Nonepileptic seizures under levetiracetam therapy: a case report of forced normalization process
title_short Nonepileptic seizures under levetiracetam therapy: a case report of forced normalization process
title_full Nonepileptic seizures under levetiracetam therapy: a case report of forced normalization process
title_fullStr Nonepileptic seizures under levetiracetam therapy: a case report of forced normalization process
title_full_unstemmed Nonepileptic seizures under levetiracetam therapy: a case report of forced normalization process
title_sort nonepileptic seizures under levetiracetam therapy: a case report of forced normalization process
publisher Dove Medical Press
series Neuropsychiatric Disease and Treatment
issn 1178-2021
publishDate 2014-05-01
description Francesca Anzellotti, Raffaella Franciotti, Holta Zhuzhuni, Aurelio D'Amico, Astrid Thomas, Marco Onofrj Department of Neuroscience and Imaging, Aging Research Centre, Gabriele d'Annunzio University Foundation, Gabriele d'Annunzio University, Chieti, Italy Abstract: Nonepileptic seizures (NES) apparently look like epileptic seizures, but are not associated with ictal electrical discharges in the brain. NES constitute one of the most important differential diagnoses of epilepsy. They have been recognized as a distinctive clinical phenomenon for centuries, and video/electroencephalogram monitoring has allowed clinicians to make near-certain diagnoses. NES are supposedly unrelated to organic brain lesions, and despite the preponderance of a psychiatric/psychological context, they may have an iatrogenic origin. We report a patient with NES precipitated by levetiracetam therapy; in this case, NES was observed during the disappearance of epileptiform discharges from the routine video/electroencephalogram. We discuss the possible mechanisms underlying NES with regard to alternative psychoses associated with the phenomenon of the forced normalization process. Keywords: nonepileptic seizures, forced normalization, levetiracetam, behavioral side effects
url http://www.dovepress.com/nonepileptic-seizures-under-levetiracetam-therapy-a-case-report-of-for-a16991
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