HSV-1 Oncolytic Viruses from Bench to Bedside: An Overview of Current Clinical Trials

HSV-1 Oncolytic Viruses from Bench to Bedside: An Overview of Current Clinical Trials

Herpes simplex virus 1 (HSV-1) provides a genetic chassis for several oncolytic viruses (OVs) currently in clinical trials. Oncolytic HSV1 (oHSV) have been engineered to reduce neurovirulence and enhance anti-tumor lytic activity and immunogenicity to make them attractive candidates in a range of on...

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Bibliographic Details
Main Authors: Marilin S. Koch, Sean E. Lawler, E. Antonio Chiocca
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:Cancers
Subjects:
HSV-1
oncolytic virus
immunotherapy
clinical trials
Online Access:https://www.mdpi.com/2072-6694/12/12/3514

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